Summary
The familial occurrence of achalasia has been previously recorded and a genetic origin for the disease has been postulated. We present the first case of achalasia in monozygotic twins and suggest that concordance for the disease is consistent with a genetic factor in the etiology of achalasia.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Mackler D, Schneider R: Achalasia in father and son. Am J Dig Dis 23:1042–1045, 1978
Westley CR, Herbst JJ, Goldman S, Wiser WC: Infantile achalasia inherited as an autosomal recessive disorder. J Pediatr 87:243–246, 1975
Dayalan N, Chettur L, Ramatnishnan MS: Achalasia of the cardia in siblings. Arch Dis Child 47:115–118, 1972
Rozyki DL, Ruben RJ, Rapin I, Spiro AJ: Autosomal recessive deafness associated with short stature, vitiligo, muscle wasting and achalasia. Arch Otolaryngol 93:194–197, 1971
Eckrich JD, Winans CS: Discordance for achalasia in identical twins. Dig Dis Sci 24:221–224, 1979
Earlam RJ, Ellis FH Jr, Nobrega FT: Achalasia of the esophagus in a small urban community. Mayo Clin Proc 44:478–483, 1969
Ellis FH Jr, Olsen AM: Achalasia of the Esophagus. Philadelphia, WB Saunders, 1969, pp 66–68
Mood AM: Introduction to the Theory of Statistics, 3rd ed. New York, McGraw-Hill, 1974, pp 93–98
Kilpatrick ZM, Milles SS: Achalasia in mother and daughter. Gastroenterology 62:1042–1046, 1972
Thibert F, Chicoine R, Chartier-Ratelle G, Thibadeau LP, Collin PP, Colla R: Forme familiale de l'achalasie de l'oeophage chey l'entant. Union Med Can 94:1293–1300, 1965
Polonsky L, Guth PH: Familial achalasia. Am J Dig Dis 15:291–295, 1970
London FA, Raab DE, Fuller J, Olsen AM: Achalasia in three siblings. Mayo Clin Proc 52:97–100, 1977
Nagler RW, Schwartz RD, Stahl Wm Jr, Spiro HM: Achalasia in fraternal twins. Ann Intern Med 59:906–910, 1963
Smith CA: The Physiology of the Newborn Infant, 3rd ed. Springfield, Illinois, Charles C Thomas, 1959
Tyce FA, Brough W: The appearance of an undescribed syndrome and the inheritance of multiple diseases in three generations of a family. Psychiatr Res Rep Am Psychiatr Assoc 15:73–79, 1962
Cloud DT Jr, White RF, Linkner LM, Taylor LC: Surgical treatment of esophageal achalasia in children. J Pediatr Surg 1:137–144, 1966
diBello B, Zilli L: Associazione di cancro e megaso fago in duo fratelli. Acta Chir Ital 16:267–294, 1960
Vaughan WH, Williams JL: Familial achalasia with pulmonary complications in children. Radiology 107:407–409, 1973
Kaye MD, Demeules JE: Achalasia and diffuse esophageal spasm in siblings. Gut 20:811–814, 1979
Chawla K, Chawla SK, Alexander LL: Familial achalasia of the esophagus in mother and son: A possible pathogenetic relationship. J Am Geriatr Soc 27:519–521, 1979
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stein, D.T., Knauer, C.M. Achalasia in monozygotic twins. Digest Dis Sci 27, 636–640 (1982). https://doi.org/10.1007/BF01297220
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01297220