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Short-term treatment of prepyloric ulcer

Comparison of sucralfate and cimetidine

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Abstract

A double-blind, randomized, multicenter study was performed to compare the effect of sucralfate (1 g qid) and cimetidine (400 mg bid) in the treatment of prepyloric ulcer. Altogether 142 patients (68 in the sucralfate and 74 in the cimetidine group) with endoscopically confirmed ulcer within 2 cm of the pylorus completed the study. Endoscopic follow up was performed after four weeks and, if the ulcer was not healed, after eight weeks of treatment. After four weeks, 65% of the ulcers in the sucralfate group were healed, compared to 70% in the cimetidine group. There was no significant difference between sucralfate and cimetidine at either time point. The 95% confidence interval for the difference in ulcer healing with sucralfate or cimetidine ranged from +4 to −19% at eight weeks. Said another way, with an observed difference of 7% (83% vs 90%), the 95% confidence limit ranged from 4% in favor of sucralfate to 19% in favor of cimetidine. Symptomatic relief, antacid intake, and side effects did not differ significantly between the two groups. The healing rate of prepyloric ulcer in this study is similar to that reported for duodenal ulcer after four and eight weeks when treated with sucralfate or cimetidine. Sucralfate is safe and as effective as cimetidine in the short-term treatment of prepyloric ulcer.

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Authors and Affiliations

  1. Departments of Medicine and Surgery, Hospital of Bollnäs, Sweden

    L. -E. Svedberg MD, L. Carling MD,  H. Glise MD, B. Hallerbäck MD, I. Kagevi MD, J. H. Solhaug MD & L. Wählby MD

  2. Departments of Medicine and Surgery, Hospital of Skövde, Sweden

    L. -E. Svedberg MD, L. Carling MD,  H. Glise MD, B. Hallerbäck MD, I. Kagevi MD, J. H. Solhaug MD & L. Wählby MD

  3. Departments of Medicine and Surgery, Hospital of Torsby, Sweden

    L. -E. Svedberg MD, L. Carling MD,  H. Glise MD, B. Hallerbäck MD, I. Kagevi MD, J. H. Solhaug MD & L. Wählby MD

  4. Departments of Medicine and Surgery, Hospital of vänersborg, Sweden

    L. -E. Svedberg MD, L. Carling MD,  H. Glise MD, B. Hallerbäck MD, I. Kagevi MD, J. H. Solhaug MD & L. Wählby MD

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  1. L. -E. Svedberg MD
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  2. L. Carling MD
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  7. L. Wählby MD
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Svedberg, L.E., Carling, L., Glise, H. et al. Short-term treatment of prepyloric ulcer. Digest Dis Sci 32, 225–231 (1987). https://doi.org/10.1007/BF01297045

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  • DOI: https://doi.org/10.1007/BF01297045

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