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Hepatic stimulator substance

Discovery, characteristics and mechanism of action

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Abstract

Hepatic stimulator substance is a unique, 12,000-to 18,000-dalton peptide found in the liver of weanling and regenerating, but not normal, adult rats. It has also been demonstrated in dogs, rabbits, and pigs. It is organ specific, bothin vivo andin vitro, but species nonspecific. It induces liver growth after a 10-to 12-hr lag period, during which time new protein and RNA synthesis are required. The initial events induced by HSS in HTC hepatoma cellsin vitro include a rapid influx of Na+ via the Na+/H+ antiport and a rapid influx of extracellular Ca2+. The rise in intracellular Ca2+ appears to be dependent on the influx of Na+ and the influx of Na+ is necessary, but not in itself sufficient, to stimulate DNA synthesis.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Iowa College of Medicine, 52242, Iowa City, Iowa

    Doublas R. LaBrecque MD

  2. Iowa City Veterans Administration Hospital, 52242, Iowa City, Iowa

    Doublas R. LaBrecque MD

Authors
  1. Doublas R. LaBrecque MD
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Additional information

This work was supported by the Veterans Administration and NCI Research Grant RO1 CA 29101.

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LaBrecque, D.R. Hepatic stimulator substance. Digest Dis Sci 36, 669–673 (1991). https://doi.org/10.1007/BF01297036

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  • DOI: https://doi.org/10.1007/BF01297036

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