Summary
Peutz-Jeghers syndrome is a genetic condition characterized by mucocutaneous pigmentation and gastrointestinal polyposis. A variety of neoplasms have been found in the alimentary tract or else-where in patients with this entity. A 39-year-old female patient who had carcinoma and two polyps in the gallbladder in association with Peutz-Jeghers syndrome is described. Since the polyps consisted of the normal lining epithelium of the gallbladder and pseudopyloric gland-type metaplastic cells and obviously lacked cellular atypism, the authors would consider them hamartomatous. The carcinoma partly showing submucosal invasion existed in an area other than the polyps. This is the first documented case of the syndrome having gallbladder carcinoma.
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Dozois RR, Judd ES, Dahlin DC, Bartholomew LG: The Peutz-Jeghers syndrome. Arch Surg 98:509–551, 1969
Dodds WJ, Schulte WJ, Hensley GT, Hogan WJ: Peutz-Jeghers syndrome and gastrointestinal malignancy. Am J Roentgenol Rad Ther Nucl Med 115:374–377, 1972
Trau H, Schewach-Millet M, Fisher BK, Tsur H: Peutz-Jeghers syndrome and bilateral breast carcinoma. Cancer 50:788–792, 1982
Utsunomiya J, Gocho H, Miyanaga T, Hamaguchi E, Kashimura A: Peutz-Jeghers syndrome: Its natural course and management. Johns Hopkins Med J 136:71–82, 1975
Dubois RS, Hoffman WH, Krishman TH, Rising JA, Tolia VK, Sy DA, Chang CH: Feminizing sex cord tumor with annular tubules in a boy with Peutz-Jeghers syndrome. J Pediatr 101:568–571, 1982
Lehur P-A, Madarnas P, Devroede G, Perey BJ, Menard DB, Hamade N: Peutz-Jeghers syndrome. Association of duodenal and bilateral breast cancers in the same patient. Dig Dis Sci 29:178–182, 1984
Bolwell JS, James PD: Peutz-Jeghers syndrome with pseudoinvation of hamartomatous polyps and multiple epithelial neoplasms. Histopathology 3:39–50, 1979
Parker MCO, Knight M: Peutz-Jeghers syndrome causing obstructive jaundice due to polyp in common bile duct. R Soc Med 76:701–703, 1983
Foster DR, Foster DBE: Gallbladder polyps in Peutz-Jeghers syndrome. Postgrad Med J 56:373–376, 1980
Morson BC: Some peculiarities in histology of intestinal polyps. Dis Colon Rectum 5:337–344, 1962
Halbert RE: Peutz-Jeghers syndrome with metastasizing gastric adenocarcinoma. Report of a case. Arch Pathol Lab Med 106:517–520, 1982
Burdick D, Prior JT: Peutz-Jeghers syndrome. A clinicopathologic study of a large family with a 27-year follow-up. Cancer 50:2139–2146, 1982
Perzin KH, Bridge MF: Adenomatous and carcinomatous changes in hamartomatous polyps of the small intestine (Peutz-Jeghers syndrome): Report of a case and review of the literature. Cancer 49:971–983, 1982
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Wada, K., Tanaka, M., Yamaguchi, K. et al. Carcinoma and polyps of the gallbladder associated with Peutz-Jeghers syndrome. Digest Dis Sci 32, 943–946 (1987). https://doi.org/10.1007/BF01296719
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DOI: https://doi.org/10.1007/BF01296719