Abstract
Upper gastrointestinal (UGI) endoscopy was performed in 41 asymptomatic American patients with familial polyposis to assess the prevalence of gastric and duodenal polyps and to characterize their pathological features. Eighteen patients (44%) had UGI endoscopic abnormalities. Six patients had both gastric and duodenal lesions. Eight patients had only gastric polyps, and four had duodenal polyps only. The presence of other extracolonic expressions of polyposis had a suggestive but statistically insignificant correlation with UGI polyps. Patients with familial polyposis and duodenal adenomatous polyps are at high risk for the development of periampullary cancer; screening and identification of these individuals is recommended.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bussey HJR: Familial Polyposis Coli. Baltimore, Johns Hopkins University Press, 1975
Cohen SH: Familial polyposis coli and its extracolonic manifestations. J Med Genet 19:193–203, 1982
Sener SF, Miller HH, DeCosse JJ: The spectrum of polyposis. Surg Gynecol Obstet 159:525–532, 1984
Hauser G: Ueber polyposis intestinal adenomatosa und dereu beziehungen zur krebsentwicklung. Dtsch Arch Klin Med 55:429–448, 1895
Halsted JA, Harris EJ, Bartlett MK: Involvement of the stomach in familial polyposis of the gastrointestinal tract. Gastroenterology 15:763–770, 1950
Mayo CW: Discussion of paper by Estes WL. Ann Surg 127:1055–1056, 1949
Utsunomiya J, Maki T, Iwama T, Matsunaga Y, Ichikawa T, Shimomura T, Hamaguchi E, and Aoki N: Gastric lesions of familial polyposis coli. Cancer 34:745–754, 1974
Ushio K, Sasagawa M, Doi H, Yamada T, Ichikawa, H, Hojo K, Koyama Y, Sano R: Lesions associated with familial polyposis coli: studies of lesions of the stomach, duodenum, bones and teeth. Gastrointest Radiol 1:67–80, 1976
Watanabe H, Enjoji M, Yoo T, Ohsoto K: Gastric lesions in familial adenomatosis coli: Their incidence and histologic analysis. Hum Pathol 9:269–283, 1978
Bulow S, Laurifsen KB, Johansen A, Svendsen LB, Sondergaard JO: Gastroduodenal polyps in familial polyposis coli. Dis Colon Rectum 28:90–93, 1985
Jarvinen H, Nyberg M, Peltoralleo P: Upper gastrointestinal tract polyps in familial adenomatosis coli. Gut 24:333–339, 1983
Sivak MV, Jagelman DG: Upper gastrointestinal endoscopy in polyposis syndromes: Familial polyposis coli and Gardner's syndrome. Gastrointest Endosc 30:102–104, 1984
Burt RW, Berenson MM, Lee RG, Tolman KG, Freston JW, Gardner ES: Upper gastrointestinal polyps in Gardner's syndrome. Gastroenterology 86:295–301, 1984
Ranzi T, Castagnone D, Velio P, Bianchi P, Polli EE: Gastric and duodenal polyps in familial polyposis coli. Gut 22:363–367, 1981
Hamilton SR, Bussey HJR, Mendelsohn G, Diamond MP, Pavlides G, Hutcheon D, Harbison M, Shermeta D, Morson BC, and Yardley JH: Ileal adenomas after colectomy in nine patients with adenomatous polyposis coli/Gardner's syndrome. Gastroenterology 77:1252–1257, 1979
Hoffman DC, Goligher JC: Polyposis of the stomach and small intestine in association with familial polyposis coli. Br J Surg 58:126–128, 1971
Schulman A: Gastric and small bowel polyps in Gardner's syndrome and familial polyposis coli. J Can Assoc Radiol 27:206–209, 1976
Cabot RC: Case records of the Massachusetts General Hospital case 21601. N Engl J Med 212:263–267, 1935
Ungar H: Familial carcinoma of the duodenum in adolescence. Br J Cancer 3:321–330, 1949
Scully RE, Mark EJ, McNeely BU: Case records of the Massachusetts General Hospital. N Engl J Med 307:1566–1573, 1982
Jarvinen HJ, Nyberg M, Peltokallio P: Biliary involvement in familial adenomatosis coli. Dis Colon Rectum 26:525–528, 1983
Bombi JA, Rives A, Astudillo E, Pera C, Cardesa A: Polyposis coli associated with adenocarcinoma of the gallbladder, report of a case. Cancer 53:2561–2563, 1984
Coffey RJ, Knight CD, Van Heerden JA, Weiland LH: Gastric adenocarcinoma complicating Gardner's syndrome in a North American woman. Gastroenterology 88:1263–1266, 1985
Gardner EJ, Richards RC: Multiple cutaneous and subcutaneous lesions occurring simultaneously with hereditary polyposis and osteomatosis. Am J Hum Genet 5:139–147, 1953
Gardner EJ: Follow-up study of family group exhibiting dominant inheritance for a syndrome including intestinal polyps, osteomas, fibromas and epidermoid cysts. Am J Hum Genet 14:376–390, 1962
Nishiura M, Hirota T, Itabashi M, Oshio K, Yamada T, Oguro Y: A clinical and histopathological study of gastric polyps in familial polyposis coli. Am J Gastroenterol 79:98–103, 1984
Iida M, Yao T, Watanabe H, Itoh H, Iwashita A: Fundic gland polyposis in patients without familial adenomatosis coli: Its incidence and clinical features. Gastroenterology 86:1437–1442, 1984
Iida M, Yao T, Itoh H, Ohsato K, Watanabe H: Endoscopic features of adenoma of the duodenal papilla in familial polyposis of the colon. Gastrointest Endosc 27:6–8, 1981
Yao T, Iida M, Ohsato K, Watanabe H, Omae T: Duodenal lesions in familial polyposis of the colon. Gastroenterology 73:1086–1092, 1977
Pauli RM, Pauli ME, Hall JG: Gardner's syndrome and periampullary malignancy. Am J Med Genet 6:205–219, 1980
Jones TR, Nance FC: Periampullary malignancy in Gardner's syndrome. Ann Surg 185:565–573, 1977
Sugihara K, Mato T, Kamiya J, Konishi F, Sawada T, Morika Y: Gardner's syndrome associated with periampullary carcinoma, duodenal and gastric adenomatosis. Dis Colon Rectum 25:766–771, 1982
Kozuka S, Tsubone M, Yamaguchi A, Hachisaka K: Adenomatous residue in cancerous papilla of Vater. Gut 22:1031–1034, 1981
Author information
Authors and Affiliations
Additional information
Supported in part by NIH grant CA-31711
Rights and permissions
About this article
Cite this article
Kurtz, R.C., Sternberg, S.S., Miller, H.H. et al. Upper gastrointestinal neoplasia in familial polyposis. Digest Dis Sci 32, 459–465 (1987). https://doi.org/10.1007/BF01296027
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01296027