Summary
We report −108Met/Val polymorphism of the COMT gene in Japanese patients with Parkinson's disease (PD). The allele frequency for −108Val was higher in PD patients compared with controls, although the differences did not reach the statistical significance. However, the frequency of -108Val homozygotes was significantly higher in PD patients (56.8%) than in control subjects (44.2%), and heterozygotes of −108Met/Val were less in PD. COMT gene polymorphism may constitute a genetic risk factor for PD among Japanese.
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References
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Yoritaka, A., Hattori, N., Yoshino, H. et al. Catechol-O-methyltransferase genotype and susceptibility to Parkinson's disease in Japan. J. Neural Transmission 104, 1313–1317 (1997). https://doi.org/10.1007/BF01294732
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DOI: https://doi.org/10.1007/BF01294732