Summary
Male Sprague-Dawley rats were treated for 7 days with the norepinephrine (NE) uptake inhibitors desipramine (DMI) or (+)-oxaprotiline or the inactive (−)-enantiomer of oxaprotiline. DMI, as previously reported, significantly increased hippocampal glucocorticoid receptor (GR) mRNA while the equipotent NE uptake inhibitor (+)-oxaprotiline like the inactive (−)-oxaprotiline did not alter hippocampal levels of GR mRNA. The results indicate that an increase in the synaptic availability of NE as a consequence of uptake inhibition is not responsible for the action of DMI on GR gene expression.
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References
Budziszewska B, Siwanowicz J, Przegaliñski E (1994) The effect of chronic treatment with antidepressant drugs on the corticosteroid receptor levels in the rat hippocampus. Pol J Pharmacol 46: 147–152
Delini-Stula A, Hauser K, Baumann P, Olpe HR, Waldmeier P, Storni A (1982) Stereospecificity of behavioural and biochemical responses to oxaprotiline — a new antidepressant. Adv Biochem Psychopharmacol 31: 265–275
Eiring A, Manier DH, Bieck PR, Howells RD, Sulser F (1992) The “Serotonin/Norepinephrine Link” beyond the beta adrenoceptor. Mol Brain Res 16: 211–214
Kitayama I, Janson AM, Cintra A, Fuxe K, Agnati LF, Ögren SO, Harfstrand A, Eneroth P, Gustafsson JA (1988) Effects of chronic imipramine treatment on glucocorticoid receptor immunoreactivity in various regions of the rat brain. J Neural Transm 73: 191–203
Mishra R, Gillespie DD, Lovell R, Robson RD, Sulser F (1982) Oxaprotiline: induction of central noradrenergic subsensitivity by its (+)-enantiomer. Life Sci 30: 1747–1755
Peiffer A, Veilleaux S, Barden N (1991) Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain. Psychoneuroendocrinology 16: 505–515
Pepin MC, Govindan MV, Barden N (1992) Increased glucocorticoid receptor gene promoter activity after antidepressant treatment. Mol Pharmacol 41: 1016–1022
Rossby SP, Nalepa I, Huang M, Burt A, Perrin C, Schmidt DE, Sulser F (1995) Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant. Brain Res 687: 79–82
Seckl JR, Fink G (1992) Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo. Neuroendocrinology 55: 621–626
Waldmeier P, Baumann P, Hansen K, Maitre L, Storni A (1982) Oxaprotiline, a noradrenaline uptake inhibitor with an active and inactive enantiomer. Biochem Pharmacol 31: 2169–2176
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Eiring, A., Sulser, F. Increased synaptic availability of norepinephrine following desipramine is not essential for increases in GR mRNA. J. Neural Transmission 104, 1255–1258 (1997). https://doi.org/10.1007/BF01294725
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DOI: https://doi.org/10.1007/BF01294725