Abstract
Many quantitative models have been developed for the biological effectiveness of radiation of different quality. They differ substantially in their assumptions, and a lack of firm knowledge remains as to the detailed nature of the critical early molecular damage. Analyses of microscopic features of the stochastic structures of radiation tracks have led to hypotheses on the importance of clustered damage in DNA and associated molecules. Clustered damage of greater complexity or severity is suggested to be less repairable and therefore to dominate the biological consequences.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Barendsen GW (1994) RBE-LET relationships for different types of lethal damage in mammalian cells: biophysical and molecular mechanisms. Radiat Res 139:257–270
Brenner DJ, Ward JF (1992) Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. Int J Radiat Biol 61:737–748
Brenner DJ, Zaider M (1983) Modification of the theory of dual radiation action for attenuated fields. II. Application to the analysis of soft X-ray results. Radiat Res 99:43–70
Chadwick K, Leenhouts HP (1981) The molecular theory of radiation biology. Springer, Berlin Heidelberg New York
Charlton DE, Nikjoo J, Humm JL (1989) The calculation of initial yields of single-and double-strand breaks in cell nuclei from electrons, protons and alpha particles. Int J Radiat Biol 56:1–19
Chatterjee A, Holley WR (1993) Computer simulation of initial events in the biochemical mechanisms of DNA damage. Adv Radiat Biol 17:181–226
Chetioui A, Despiney I, Guiraud L, Adou L, Sabatier I, Dutrillaux B (1994) Possible role of inner-shell ionization phenomena in cell inactivation by heavy ions. Int J Radiat Biol 65:511–522
Curtis S (1986) Lethal and potentially lethal lesions induced by radiation- a unified repair model. Radiat Res 106:252–270
Goodhead DT (1980) An assessment of the role of microdosimetry in radiobiology. Radiat Res 91:45–76
Goodhead DT (1985) Saturable repair models of radiation action in mammalian cells. Radiat Res 104:S58–67
Goodhead DT (1987a) Relationship of microdosimetric techniques to applications in biological systems. In: Kase KR, Bjarngaard BE, Attix FH (eds) The dosimetry of ionising radiations, vol. II. Academic Press, Orlando
Goodhead DT (1987b) Biophysical models of radiation action; introductory review. In: Fielden EM, Fowler JF, Hendry JH, Scott D (eds) Radiation research. Taylor & Francis, London
Goodhead DT (1987c) Physical basis of biological effect. (Nuclear and atomic data for radiotherapy and related radiobiology) IAEA, Vienna
Goodhead DT (1989a) The initial physical damage produced by ionizing radiations. Int J Radiat Biol 56:623–634
Goodhead DT (1989b) Relationship of radiation track structure to biological effect: a re-interpretation of the parameters of the Katz model. Nucl Tracks Radiat Meas 16:177–184
Goodhead DT (1994a) Soft X-ray radiobiology and synchrotron radiation. In: Chance B et al. (eds) Synchrotron radiation in the biosciences. Oxford University Press, Oxford
Goodhead DT (1994b) Initial events in the cellular effects of ionizing radiations: clustered damage in DNA. Int J Radiat Biol 65:7–17
Goodhead DT, Brenner DJ (1983) Estimation of a single property of low LET radiations which correlates with biological effectiveness. Phys Med Biol 28:485–492
Goodhead DT, Charlton DE (1985) Analysis of high-LET radiation effects in terms of local energy deposition. Radiat Prot Dosim 13:253–258
Goodhead DT, Nikjoo H (1989) Track structure analysis of ultrasoft X-rays compared to high-and low-LET radiations. Int J Radiat Biol 55:513–529
Goodhead DT, Thacker J, Cox R (1993) Effects of radiations of different qualities on cells: molecular mechanisms of damage and repair. Int J Radiat Biol 63:543–556
Griffiths SD, Marsden SJ, Wright EG, Greaves MF, Goodhead DT (1994) Lethality and mutagenesis of B lymphocyte progenitor cells following exposure to α-particles and X-rays. Int J Radiat Biol 66:197–205
Hagen U (1994) Mechanisms of induction and repair of DNA double-strand breaks by ionizing radiation: some contradictions. Radiat Environ Biophys 13:33–45
Howard-Flanders P (1958) Physical and chemical mechanisms in the injury of cells by ionizing radiations. Adv Biol Med Phys 6:553–603
Ito A (1987) Calculation of double strand break probability of DNA for low LET radiations based on track structure analysis. (Nuclear and atomic data for radiotherpy and related radiobiology) IAEA, Vienna
Jenner TJ, de Lara CM, O'Neill P, Stevens DL (1993) Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following γ- and α-irradiation. Int J Radiat Biol 64:265–273
Katz R, Ackerson B, Homayoonfar M, Sharma SC (1971) Inactivation of cells by heavy ion bombardment. Radiat Res 47:402–425
Kellerer AM, Rossi HH (1978) A generalized formulation of dual radiation action. Radiat Res 75:471–488
Kraft G (1992) LET, track structure and models. Radiat Environ Biophys 31:161–180
Lea DE (1946) Actions of radiations on living cells. Cambridge University Press, London
Michalik V (1991) Particle track structure and its correlation with radiobiological endpoint. Phys Med Biol 36:1001–1012
Moolgavkar SH (1992) Cancer models. In: Chadwick KH, Moschini G, Varma MN (eds) Biophysical modelling of radiation effects. Adam Hilger, Bristol
Nikjoo H, Charlton DE, Goodhead DT (1994a) Monte Carlo track structure studies of energy deposition and calculation of initial DSB and RBE. Adv Space Res 14:161–180
Nikjoo H, O'Neill P, Terrissol M, Goodhead DT (1994b) Modelling of radiation-induced DNA damage: the early physical and chemical events. Int J Radiat Biol (in press)
Obaturov GM, Filimonov AS, Moiseenko VV (1993) Model of mammalian cell reproductive death. II. Comparison with experimental data and discussion. Radiat Environ Biophys 32:295–310
Paretzke HP (1987) Radiation track structure theory. In: Freeman GP (ed) Kinetics of nonhomogenous processes. Wiley, New York
Prise K (1994) Use of radiation quality as a probe for DNA lesion complexity. Int J Radiat Biol 65:43–48
Sanchez-Reyes (1992) A simple model of radiation action in cells based on a repair saturation mechanism. Radiat Res 130:139–147
Terrissol M, Pomplun E (1994) Computer-simulation of DNA-incorporated125I Auger cascades and of the associated radiation chemistry in aqueous solution. Radiat Prot Dosim 52:177–181
Tubiana M, Dutreix J, Wambersie A (1990) Introduction to radiobiology. Taylor & Francis, London
Ward JF (1985) Some biological consequences of the spatial distribution of ionizing radiation-produced free radicals. Radiat Res 86:185–195
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goodhead, D.T. Molecular and cell models of biological effects of heavy ion radiation. Radiat Environ Biophys 34, 67–72 (1995). https://doi.org/10.1007/BF01275208
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01275208