Summary
The effects of anesthesia on dopamine D2 receptor binding in the rhesus monkey brain were examined using positron emission tomography. The bindings of11C-N-methylspiperone (NMSP) and11C-raclopride (RAC) were measured under controlled ketamine or isoflurane anesthesia. The binding of11C-NMSP was significantly lower in the striatum anesthetized with isoflurane than with ketamine. There was a smaller change in the binding of11C-RAC than of11C-NMSP. These findings suggest that changes in11C-NMSP or11C-RAC binding induced by anesthetics were not due solely to changes in the competition of endogenous dopamine.
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Kobayashi, K., Inoue, O., Watanabe, Y. et al. Difference in response of D2 receptor binding between11C-N-methylspiperone and11C-raclopride against anesthetics in rhesus monkey brain. J. Neural Transmission 100, 147–151 (1995). https://doi.org/10.1007/BF01271537
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DOI: https://doi.org/10.1007/BF01271537