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Frequency domain source localization shows state-dependent diazepam effects in 47-channel EEG

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Summary

The topic of this study was to evaluate state-dependent effects of diazepam on the frequency characteristics of 47-channel spontaneous EEG maps. A novel method, the FFT-Dipole-Approximation (Lehmann and Michel, 1990), was used to study effects on the strength and the topography of the maps in the different frequency bands. Map topography was characterized by the 3-dimensional location of the equivalent dipole source and map strength was defined as the spatial standard deviation (the Global Field Power) of the maps of each frequency point. The Global Field Power can be considered as a measure of the amount of energy produced by the system, while the source location gives an estimate of the center of gravity of all sources in the brain that were active at a certain frequency. State-dependency was studied by evaluating the drug effects before and after a continuous performance task of 25 min duration. Clear interactions between drug (diazepam vs. placebo) and time after drug intake (before and after the task) were found, especially in the inferior-superior location of the dipole sources. It supports the hypothesis that diazepam, like other drugs, has different effects on brain functions depending on the momentary functional state of the brain. In addition to the drug effects, clearly different source locations and Global Field Power were found for the different frequency bands, replicating earlier reports (Michel et al., 1992).

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References

  • Alvarez A, Pascual RD, Valdes P (1990) Spatiotemporal properties of the alpha rhythm. In: John ER (ed) Machinery of the mind-data, theory, and speculations about higher brain function. Birkhäuser, Boston, pp 435–459

    Google Scholar 

  • Binnie CD, Comer AK (1978) The effect of cigarette smoking on the contingent negative variation and eye movement. In: Thornton RE (ed) Smoking behavior: physiological and psychological influences. Churchill Livingston, Edinburgh, pp 69–75

    Google Scholar 

  • Bond A, Lader M, Shrotriya R (1983) Comparative effects of a repeated dose regime of diazepam and buspirone on subjective ratings, psychological tests and the EEG. Eur J Clin Pharmacol 24: 463–467

    PubMed  Google Scholar 

  • Bracewell RN (1984) The fast Hartley transform. Proc IEEE 72: 1010

    Google Scholar 

  • Coppola R, Herrmann WM (1987) Psychotropic drug profiles: comparisons by topographic maps of absolute power. Neuropsychobiology 18: 97–104

    PubMed  Google Scholar 

  • Dierks T (1992) Equivalent EEG sources determined by FFT-approximation in healthy subjects, schizophrenic and depressive patients. Brain Topogr 4: 207–213

    PubMed  Google Scholar 

  • Dierks T, Engelhardt W, Maurer K (1993) Equivalent dipoles of FFT data visualize drug interaction at benzodiazepine receptors. Electroencephalogr Clin Neurophysiol 86: 231–237

    PubMed  Google Scholar 

  • Duffy FH, Burchfiel JL, Lombroso CT (1979) Brain electrical activity mapping (BEAM): a method for extending the clinical utility of EEG and evoked potential data. Ann Neurol 5: 309–321

    PubMed  Google Scholar 

  • Dummermuth G, Ferber G, Hermann WM, Hinrichs H, Kunkel H (1987) Recommendations for standardization and signal analysis in pharmaco-electroencephalography. Neuropsychobiology 17: 213–218

    PubMed  Google Scholar 

  • Fender DH (1987) Source localization of brain electrical activity. In: Gevins AS, Remond A (eds) Handbook of electroencephalography and clinical neurophysiology, vol 1. Methods of analysis of brain electrical and magnetic signals. Elsevier, Amsterdam, pp 355–399

    Google Scholar 

  • Fink M (1984) Pharmacoelectroencephalography: a note in history. Neuropsychobiology 76: 271–276

    Google Scholar 

  • Herrmann WM (1982 a) Electroencephalography and drug research. Fischer, Stuttgart

    Google Scholar 

  • Herrmann WM (1982 b) Development and critical evaluation of an objective procedure for the electroencephalographic classification of psychotropic drugs. In: Herrmann WM (ed) Electroencephalography in drug research. Fischer, Stuttgart, pp 249–351

    Google Scholar 

  • Herrmann WM, Abt K, Coppola R, Etevenon ET, Ferber G, Fink M, Gevins AS, Hinrichs H, Itil TM, John ER, Kubicki S, Künkel H, Kugler J, Lehmann D, Petsche H, Rappelsberger P, Röhmel J, Saito M, Saletu B, Scheuler W (1989) International Pharmaco-EEG Group (IPEG). Recommendation for EEG and evoked potential mapping. Neuropsychobiology 22: 170–176

    PubMed  Google Scholar 

  • Herrmann WM, Fichte K, Kubicki St (1980) Definition von EEG-Frequenzbändern aufgrund strukturanalytischer Betrachtungen. In: Kubicki St, Herrmann WM, Lauchahn G (eds) Faktoranalyse und Variablenbildung aus dem Elektroenzephalogramm. Gustav Fischer, Stuttgart New York, pp 61–74

    Google Scholar 

  • Itil TM (1974) Quantitative pharmaco-electroencephalography. Use of computerized cerebral potentials in psychotropic drug research. In: Itil TM (ed) Psychotropic drugs and the human EEG. Karger, Basel, pp 43–75

    Google Scholar 

  • Kinoshita T, Michel CM, Yagyu T, Lehmann D, Saito M (1994) Diazepam and sulpiride effects on frequency domain EEG source locations. Neuropsychobiology 30: 126–131

    PubMed  Google Scholar 

  • Koukkou M (1980) EEG states of the brain, information processing and schizophrenic primary symptoms. Psychiat Res 6: 235–244

    Google Scholar 

  • Leeuwen TH van (1993) Effects of benzodiazepines on electrocortical brain activity and vigilance performance in humans. Thesis, University of Utrecht

  • Leeuwen TH van, Verbaten MN, Koelega HS, Kenemans JL, Slangen JL (1992) Effects of bromazepam on single-trial event-related potentials in a visual vigilance task. Psychopharmacology 106: 555–564

    PubMed  Google Scholar 

  • Lehmann D (1971) Multichannel topography of human alpha EEG fields. Electroencephalogr Clin Neurophysiol 31: 439–449

    PubMed  Google Scholar 

  • Lehmann D (1987) Principles of spatial analysis: In: Gevins AS, Remond A (eds) Handbook of electroencephalography and clinical neurophysiology, vol 1. Methods of analysis of brain electrical and magnetic signals. Elsevier, Amsterdam, pp 309–354

    Google Scholar 

  • Lehmann D, Skrandies W (1980) Reference-free identification of components of checker-board-evoked multichannel potential fields. Electroencephalogr Clin Neurophysiol 48: 609–621

    PubMed  Google Scholar 

  • Lehmann D, Michel CM (1989) Intracerebral dipole sources of EEG FFT power maps. Brain Topogr 2: 155–164 [Erratum: (1990) 2: 311]

    PubMed  Google Scholar 

  • Lehmann D, Michel CM (1990) Intracerebral source localization for FFT power maps. Electroencephalogr Clin Neurophysiol 76: 271–276

    PubMed  Google Scholar 

  • Lehmann D, Henggeler B, Koukkou M, Michel CM (1993 a) Source localization of brain electric field frequency bands during conscious, spontaneous, visual imagery and abstract thought. Cogn Brain Res 1: 203–210

    Google Scholar 

  • Lehmann D, Wackermann J, Michel CM, Koenig T (1993 b) Space-oriented EEG segmentation reveals changes in brain electric field maps under the influence of a nootropic drug. Psychiatry Res Neuroimaging 50: 275–282

    Google Scholar 

  • Linnoila M, Erwin CW, Brendle A, Simpson D (1983) Psychomotor effects of diazepam in anxious patients and healthy volunteers. J Clin Psychopharmacol 3: 88–96

    PubMed  Google Scholar 

  • Lütkenhöner B (1992) Frequency-domain localization of intracerebral dipolar sources. Electroencephalogr Clin Neurophysiol 82: 112–118

    PubMed  Google Scholar 

  • Michel C, Bättig K (1989) Separate and combined psychophysiological effects of cigarette smoking and alcohol consumption. Psychopharmacology 97: 65–73

    PubMed  Google Scholar 

  • Michel C, Nil R, Buzzi R, Woodson PP, Bättig K (1987) Rapid information processing and concomitant event-related brain potentials in smokers differing in CO absorption. Neuropsychobiology 17: 161–168

    PubMed  Google Scholar 

  • Michel CM, Lehmann D (1993) Single doses of Piracetam affect 42-channel event-related potential microstate maps in a cognitive paradigm. Neuropsychobiology 28: 212–221

    PubMed  Google Scholar 

  • Michel CM, Lehmann D, Henggeler B, Brandeis D (1992) Localization of sources of EEG delta, theta, alpha and beta frequency bands using the FFT dipole approximation. Electroencephalogr Clin Neurophysiol 82: 38–44

    PubMed  Google Scholar 

  • Michel CM, Henggeler B, Brandeis D, Lehmann D (1993 b) Localization of sources of brain alpha/theta/delta activity and the influence of the mode of spontaneous mentation. Physiol Meas 14: A21-A26

    PubMed  Google Scholar 

  • Michel CM, Koukkou M, Lehmann DD (1993 b) EEG reactivity in high and low symptomatic schizophrenics, using source modelling in the frequency domain. Brain Topogr 5: 389–394

    PubMed  Google Scholar 

  • Michel CM, Brandeis D, Skrandies W, Pascual-Marqui RD, Strik WK, Dierks T, Hamburger HL, Karniski W (1993 c) Global Field Power: a “time honored” index for EEG/EP map analysis. Int J Psychophysiol 15: 1–2

    PubMed  Google Scholar 

  • Michel CM, Kaufman L, Williamson SJ (1994) Duration of EEG and MEG Alpha suppression increases with angle in a mental rotation task. J Cogn Neurosci (in press)

  • Offner FF (1950) The EEG as potential mapping: the value of the average monopolar reference. Electroencephalogr Clin Neurophysiol 2: 215–216

    PubMed  Google Scholar 

  • Oldfield RC (1970) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9: 97–113

    Google Scholar 

  • Pascual-Marqui RD, Lehmann D (1993) Topographic maps, source localization inference, and the reference electrode: comments on a paper by Desmedt et al. Electroencephalogr Clin Neurophysiol 88: 532–533

    PubMed  Google Scholar 

  • Pascual-Marqui RD, Valdes P, Alvarez A (1988) A parametric model for multichannel EEG spectra. Int J Neurosci 40: 89–99

    PubMed  Google Scholar 

  • Pasqual-Marqui RD, Michel CM, Lehmann D (1994) Low resolution electromagnetic tomography: a new method to localize electrical activity in the brain. Int J Psychophysiol 18: 49–65

    PubMed  Google Scholar 

  • Saletu B, Anderer P, Kinsberger K, Grünberger J (1987) Topographic brain mapping of EEG in neuropsychopharmacology, part II. Clinical applications (pharmaco EEG imaging). Meth Find Exp Clin Pharmacol 9: 385–408

    Google Scholar 

  • Saletu B, Anderer P, Kinsberger K, Grünberger J, Sieghart W (1988) Comparative bioavailability studies with a new mixed-micelles solution of diazepam utilizing radioreceptor assay, psychometry and EEG brain mapping. Int J Clin Psychopharmacol 3: 287–323

    Google Scholar 

  • Tecce JJ, Savignano-Bowman J, Cole JO (1978) Drug effects on contingent negative variation and eyeblinks: the distraction-arousal hypothesis. In: Lipton MA, DiMascio A, Killam KF (eds) Psychopharmacology: a generation of progress. Raven Press, New York, pp 745–758

    Google Scholar 

  • Tesche C, Kajola M (1993) A comparison of the localization of spontaneous neuromagnetic activity in the frequency and time domains. Electroencephalogr Clin Neurophysiol 87: 408–416

    PubMed  Google Scholar 

  • Valdes P, Bosch J, Grave R, Hernandez J, Riera J, Pascual R, Biscay R (1992) Frequency domain models of the EEG. Brain Topogr 4: 309–319

    PubMed  Google Scholar 

  • Wackermann J, Lehmann D, Michel CM (1993) Global dimensional complexity of multichannel EEG indicates change of human brain functional state after single dose of a nootropic drug. Electroencephalogr Clin Neurophysiol 86: 193–198

    PubMed  Google Scholar 

  • Wikswo JP, Gevins A, Williamson SJ (1993) The future of the EEG and MEG. A review article. Electroencephalogr Clin Neurophysiol 87: 1–9

    PubMed  Google Scholar 

Download references

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Author notes

  1. C. M. Michel & R. D. Pascual-Marqui

    Present address: Department of Neurology, University Hospital of Geneva (HCUG), Geneva, Switzerland

  2. W. K. Strik

    Present address: University Hospital of Psychiatry, Würzburg, Federal Republic of Germany

Authors and Affiliations

  1. Brain Mapping Laboratory, Department of Neurology, University Hospital, Zürich, Switzerland

    C. M. Michel, R. D. Pascual-Marqui, W. K. Strik, T. Koenig & D. Lehmann

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  1. C. M. Michel
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  2. R. D. Pascual-Marqui
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  3. W. K. Strik
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  4. T. Koenig
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  5. D. Lehmann
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Michel, C.M., Pascual-Marqui, R.D., Strik, W.K. et al. Frequency domain source localization shows state-dependent diazepam effects in 47-channel EEG. J. Neural Transmission 99, 157–171 (1995). https://doi.org/10.1007/BF01271476

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  • DOI: https://doi.org/10.1007/BF01271476

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