Summary
The plasma insulin was measured by a radioimmunoassay method in 48 non-pregnant or pregnant women during glucose tolerance test (100 g glucose by mouth). Each of these 2 groups included non-obese, non-diabetic women, obese females and potential diabetic patients. The non-obese, non-diabetic, non-pregnant subjects showed mean plasma insulin levels of 25.2, 77.2, 57.0, 57.8 and 44.7μU/ml respectively 0, 45, 90, 135 and 180 minutes after glucose loading. The obese normoglycemic non pregnant females presented a normal fasting plasma insulin level which reaches 184.7,μU/ml 45 minutes after glucose intake. The late pregnancy (7th to 9th month) did not change the plasma insulin observed in the non-obese, non-diabetic and obese women. The non-pregnant females with potential diabetes showed a normal fasting plasma insulin with a maximum of 96.9μU/ml 90 minutes after the beginning of the test. In these patients between the 4th to the 9th month of the pregnancy, the maximum of 68.2μU/ml was only obtained 3 hours after the glucose loading.-The physio-pathological significance of these results is discussed.
Résumé
L'insuline plasmatique, mesurée par la méthode radioimmunologique, a été dosée chez 48 femmes non enceintes ou enceintes au cours de l'hyperglycémie provoquée par la prise orale de 100 g de glucose. Chacun de ces 2 groupes de patientes comprenait des femmes non obéses et non diabétiques, des patientes obéses et des femmes présentant un diabéte potentiel. Les patientes non obéses et non diabétiques présentaient en dehors de la grossesse des taux moyens d'insuline plasmatique de 25.2, 77.2, 57.0, 57.8 et 44.7μU/ml respectivement 0, 45, 90, 135 et 180 minutes après la surcharge glucosée. Les patientes obèses normoglycémiques non enceintes présentaient á jeun un taux normal d'insuline plasmatique qui atteignait 184.7μU/ml, 45 minutes après la prise du glucose. La grossesse au 3° trimestre ne modifiait pas les taux d'insuline plasmatique observés chez les femmes non obèses et non diabétiques et chez les patientes obèses. Les femmes avec un diabète potentiel et non enceintes présentaient à jeun un taux normal d'insuline plasmatique avec un maximum de 96.9μU/ml 90 minutes après le début du test. Au cours des 2° et 3° trimestres de la grossesse chez ces patientes, le maximum de 68.2μU/ml était seulement atteint 3 heures après la prise du glucose.-L'interprétation physio-pathologique de ces résultats est discutée.
Zusammenfassung
Mit einer radioimmunologischen Methode wurde das Plasmainsulin bei 48 nichtschwangeren oder schwangeren Frauen während eines Glucosetoleranztestes (100 g Glucose per os) untersucht. Jede dieser beiden Gruppen umfaßte nichtfettleibige, nichtdiabetische Frauen, fettleibige Frauen und latentdiabetische (nichtfettleibige) Frauen. Die nichtfettleibigen, nichtdiabetischen, nichtschwangeren Personen zeigten nüchtern und 45, 90, 135 und 180 Min. nach Glucosebelastung einen mittleren Plasmainsulinspiegel von 25.2, 77.2, 57.0, 57.8 und 44.7μE/ml. Die fettleibigen, nichtschwangeren Frauen mit normalen Blutzuckerwerten hatten einen normalen Nüchternplasmainsulinspiegel, der 45 min nach Glucoseaufnahme auf einen Wert von 184.7μE/ml anstieg. Bei den nichtfettleibigen, nichtdiabetischen und fettleibigen Frauen kam es im letzten Drittel der Schwangerschaft (7.–9. Monat) nicht zu einer Veränderung des Plasmainsulinspiegels. Die latent diabetischen, nichtschwangeren Frauen zeigten einen normalen Nüchternplasmainsulinspiegel mit einem Maximum von 96.9μE/ml 90 Min. nach Beginn des Testes. Bei den Patienten mit einer Schwangerschaft zwischen dem 4. und 9. Monat wurde das Maximum des Insulinspiegel von 68.2,μE/ml erst drei Stunden nach der Glucosebelastung erreicht.-Die pathophysiologische Bedeutung dieser Befunde wurde besprochen.
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This study was supported by grants from the Fondation Médicale Reine Elisabeth, the Fonds de la Recherche Scientifique Médicale, the Eli Lilly and Co, Indianapolis and the Cyanamid International, Pearl River N.Y.
Aspirant of the Fonds National de la Recherche Scientifique-Belgium.
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Lambert, A.E., Hoet, J.J. & Ekka, E. Plasma insulin levels during pregnancy, in obesity and potential diabetes. Diabetologia 2, 260–264 (1966). https://doi.org/10.1007/BF01268183
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DOI: https://doi.org/10.1007/BF01268183