Skip to main content
SpringerLink
Log in

The influence of different temperatures on mortality, virus multiplication and interferon production in adult mice infected with Coxsackie B1 virus

  • Published:
Archiv für die gesamte Virusforschung Aims and scope Submit manuscript

Summary

The influence of temperature on mortality, virus multiplication and interferon production in adult mice infected with Coxsackie B1 virus was investigated. Mice kept at +4° C had a rectal temperature which was 1.5° C lower than that of mice kept at +25° C. The animals with the lowest temperature had a higher and persistent virus content in the serum, liver and brain. All these mice succumbed, whereas the animals kept at +25° C survived. Interferon was found in connection with the high virus multiplication in mice at +4° C, but no interferon was demonstrated in mice at +25° C.

It is presumed that factors other than interferon played a decisive role in the survival from infection with this strain of Coxsackie B1 virus in the strain of mice studied.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Cole, G. A., andC. L. Wisseman: The Effect of hyperthermia on Dengue virus infection of mice. Proc. Soc. exp. Biol. (N.Y.)130, 359–363 (1969).

    Google Scholar 

  2. Fantes, K. H.: Purification, concentration and physico-chemical properties of interferons. In: “Interferons” (N. B. Finter, ed.), p. 119–180, Amsterdam: North-Holland Publishing Company, 1966.

    Google Scholar 

  3. Haahr, S.: The occurrence of interferon in the cerebrospinal fluid in patients with bacterial meningitis. Acta path. microbiol. scand.73, 264–274 (1968).

    PubMed  Google Scholar 

  4. Haahr, S.: The occurrence of virus and interferon in the spleen, serum and brain in mice after experimental infection with West Nile virus. Acta path. microbiol. scand.74, 445–457 (1968).

    PubMed  Google Scholar 

  5. Kirn, A., A. Schieffer, andR. Tinland: Lack of correlation between production of interferon and protection of temperature in mice infected with Sindbis virus. Nature (Lond.)215, 86–87 (1967).

    Google Scholar 

  6. Lwoff, A.: Death and Transfiguration of a Problem. Bact. Rev.33, 390–403 (1969).

    PubMed  Google Scholar 

  7. Marchall, I. D.: The influence of ambient temperature on the course of myxomatosis in rabbits. J. Hyg. (Lond.)57, 484–497 (1959).

    Google Scholar 

  8. Postic, B., C. de Angelis, M. K. Breinig, andM. Ho: Effect of temperature on the induction of interferons by endotoxin and virus. J. Bact.91, 1277–1281 (1966).

    PubMed  Google Scholar 

  9. Ruiz-Gomez, J., andJ. Sosa-Martinez: Virus multiplication and interferon production at different temperatures in adult mice infected with Coxsackie B1 virus. Arch. ges. Virusforsch.17, 295–300 (1965).

    PubMed  Google Scholar 

  10. Thompson, R. L.: The influence of temperature upon proliferation of infectious fibroma and infectious myxoma virusesin vivo. J. infect. Dis.62, 307–312 (1938).

    Google Scholar 

  11. Walker, D. L., andW. D. Boring: Factors influencing host-virus interactions. III. Further studies on the alteration of Coxsackie virus infection in adult mice by environmental temperature. J. Immunol.80, 39–44 (1958).

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Sven Haahr

    Present address: Institute of Medical Microbiology, University of Aarhus, Aarhus, Denmark

Authors and Affiliations

  1. Institute of Medical Microbiology, University of Aarhus, Aarhus, Denmark

    Børge Teisner

Authors
  1. Sven Haahr
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Børge Teisner
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haahr, S., Teisner, B. The influence of different temperatures on mortality, virus multiplication and interferon production in adult mice infected with Coxsackie B1 virus. Archiv f Virusforschung 42, 273–277 (1973). https://doi.org/10.1007/BF01265652

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01265652

Keywords

Search

Navigation