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The healing of wounds and scar formation under the influence of a tissue adhesion system with fibrinogen, thrombin, and coagulation factor XIII

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Summary

The present paper reports the central role of fibrin (and specifically its pre-stage, fibrinogen), thrombin and coagulation factor XIII in wound healing and scar formation. The significance of these three factors has led to the development of a tissue adhesion system on a physiological basis, which can be applied in widely varying areas of surgery.

The adhesive allows the exact, flat adaptation of the wound edges and thus promotes flawless scar formation. Two case reports complete the exposition.

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References

  1. Beck, E., Duckert, F., Ernst, M.: The influence of fibrin stabilizing factor on the growth of fibroblasts in vitro and wound healing. Thrombos. Diathes. haemorrh. (Stuttg.),6, 485 (1961)

    Google Scholar 

  2. Braun, F., Holle, J., Kovac, W., Lindner, A., Spängler, H. P.: Untersuchungen über die Replantation autologer Vollhaut mit Hilfe von hochkonzentriertem Fibrinogen und Blutgerinnungsfaktor XIII. Wien. Med. Wochenschr.125, 213 (1975)

    PubMed  Google Scholar 

  3. Cassau, D., Siewert, R., Osten, W.: Fibrinstabilisierung bei der vollständigen Wunddehiszenz. Chirurg40, 76 (1969)

    PubMed  Google Scholar 

  4. Dürr, W., Heller, W., Koslowski, L., Matis, P.: Beitrag zum Nachweis und zur klinischen Bedeutung des Faktor XIII. Med. Welt14, 761 (1969)

    Google Scholar 

  5. Haas, E.: Nahttechniken, Narben und Narbenkorrekturen. In: Plastische Chirurgie im Gesichts-Hals-Bereich Seite 47. Stuttgart: Georg Thieme 1976.

    Google Scholar 

  6. Laki, K., Lorand, J.: On the solubility of fibrin clots. Science108, 280 (1948)

    Google Scholar 

  7. Matras, H., Dinges, H. P., Lassmann, H., Mamoli, B.: Zur nahtlosen interfaszikulären Nerventransplantation im Tierexperiment. Wien. Med. Wochenschr.122, 517 (1972)

    PubMed  Google Scholar 

  8. Matras, H., Braun, F., Lassmann, H., Ammerer, H. P., Mamoli, B.: Plasma clot welding of nerves (Experimental Report). J. Maxillofac. Surg.4, 236 (1973)

    Google Scholar 

  9. Spängler, H. P.: Gewebeklebung und lokale Blutstillung mit Fibrinogen, Thrombin und Blutgerinnungsfaktor XIII (Experimentelle Untersuchungen und klinische Erfahrungen). Wien. Klin. Wochenschr.88 [Suppl.]49, 3 (1976)

    Google Scholar 

  10. Staindl, O.: Die Gewebeklebung mit hochkonzentriertem, humanen Fibrinogen am Beispiel der freien, autologen Hauttransplantation. Arch. Otorhinolaryngol.217, 219 (1977)

    PubMed  Google Scholar 

  11. Staindl, O.: Die Saundersplastik bei Morbus Osler unter Verwendung hochkonzentrierten humanen Fibrinogens als Gewebekleber. Laryngol. Rhinol. Otol. (Stuttg.)56, 887 (1977)

    Google Scholar 

  12. Staindl, O.: Frontobasale Verletzungen. Richtlinien der operativen Versorgung unter Berücksichtigung hochkonzentrierten humanen Fibrinogens als Gewebekleber. Wien. Med. Wochenschr.128, 387 (1978)

    PubMed  Google Scholar 

  13. Staindl, O.: Tissue adhesion with highly concentrated human fibrinogen in O.R.L. Ann. Otol. Rhinol. Laryngol. (in press) (1979)

  14. Tidrick, R. T., Warner, E. D.: Fibrin fixation of skin transplants. Surgery15, 90 (1944)

    Google Scholar 

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  1. Ear, Nose and Throat Department, Landeskrankenanstalten Salzburg, Müllner Hauptstraße 48, A-5020, Salzburg, Austria

    O. Staindl

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  1. O. Staindl
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Staindl, O. The healing of wounds and scar formation under the influence of a tissue adhesion system with fibrinogen, thrombin, and coagulation factor XIII. Arch Otorhinolaryngol 222, 241–245 (1979). https://doi.org/10.1007/BF01261169

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  • DOI: https://doi.org/10.1007/BF01261169

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