Summary
Transaction of the facial nerve causes proliferation of microglial cells in the facial nucleus. The miroglial cells can be seen in perineuronal and perivascular positions. A high activity of 5′-nucleotidase is demonstrated cytochemically in the plasma membranes of these cells. The increase of enzymatic sites for the production of adenosine during axonal reaction might be of functional significance for the regenerating motor neuron.
Similar content being viewed by others
References
Barron, K. D. andTuncbay, T. O. (1962) Histochemistry of acid phosphatase and thiamine pyrophosphatase during axon reaction.American Journal of Pathology 40, 637–52.
Barron, K. D. andTuncbay, T. O. (1964) Phosphatase histochemistry of feline cervical spinal cord after brachial plexectomy. Hydrolysis of beta-glycerophosphate, thiamine pyrophosphate and nucleoside diphosphates.Journal of Neuropathology and Experimental Neurology 23, 368–86.
Berne, R. M., Rubio, R. andCurnish, R. (1974) Release of adenosine from ischaemic brain.Circulation Research 35, 262–72.
Blinzinger, K. andKreutzberg, G. (1968) Displacement of synaptic terminals from regenerating motoneurons by microglial cells.Zeitschrift für Zellforschung und mikroskopische Anatomie 85, 145–57.
Cammermeyer, J. (1955) Astroglial changes during retrograde atrophy of nucleus facialis inmice.Journal of Comparative Neurology 102, 133–50.
Cammermeyer, J. (1965) Juxtavascular karyokinesis and microglia cell proliferation during retrograde reaction in the mouse facial nucleus.Ergebnisse der Anatomie und Entwicklungsgeschichte 38, 1–22.
Florendo, N. T., Barrnett, R. J. andGreengard, P. (1971) Cyclic 3′,5′-nucleotide phosphodiesterase: cytochemical localization in cerebral cortex.Science 173, 745–7.
Friede, R. L. andJohnstone, M. A. (1967) Responses of thymidine labeling of nuclei in gray matter and nerve following sciatic transection.Acta neuropathologica (Berlin) 7, 218–31.
Karlsson, U. andSchultz, R. L. (1965) Fixation of the central nervous system for electron microscopy by aldehyde perfusion.Journal of Ultrastructure Research 12, 160–86.
Kirkpatrick, J. B. (1968) Chromatolysis in the hypoglossal nucleus of the rat: an electron microscopic analysis.Journal of Comparative Neurology 132, 189–212.
Kreutzberg, G. W. (1966) Autoradiographische Untersuchung über die Beteiligung von Gliazellen an der axonalen Reaktion im Facialiskern der Ratte.Acta neuropathologica (Berlin) 7, 149–61.
Kreutzberg, G. W. (1967) DNA metabolism in glial cells during retrograde changes. InMacromolecules and the Function of the Neuron, (edited byLodin, Z. andRose, S. P. R.) pp. 51–7, Amsterdam: Excerpta Medica.
Kreutzberg, G. W. (1968) Über perineuronale Mikrogliazellen — Autoradiographische Untersuchungen.Acta neuropathologica Suppl.IV, 141–5.
Kreutzberg, G. W., Barron, K. D. andSchubert, P. (1978) Cytochemical localization of 5′ -nucleotidase in glial plasma membranes.Brain Research (in press).
Mcilwain, H. (1974) Regulatory significance of the release and action of adenine derivatives in cerebral systems.Biochemical Society Symposium 36, 69–85.
Nissl, F. (1894) Über eine neue Untersuchungsmethode des Centralorgans speziell zur Feststellung der Lokalisation der Nervenzellen.Zentralblatt für Nervenheilkunde und Psychiatrie 17, 337–44.
Phillis, J. W. andKostopoulos, G. K. (1975) Adenosine as a putative transmitter in the cerebral cortex. Studies with potentiators and antagonists.Life Sciences 17, 1085–94.
Rapos, M. andBakos, J. (1959) Veränderungen der Neuroglia im Nucleus originis nervi hypoglossi nach mechanischer Beschädigung des Nervus hypoglossus.Zeitschrift für mikroskopischanatomischeForschung 65, 211–8.
Sattin, A. andRall, T. W. (1970) Cyclic AMP content of guinea pig cerebral cortex slices.Molecular Pharmacology 6, 13–23.
Schubert, P. andKreutzberg, G. W. (1974) Axonal transport of adenosine and uridine derivatives and transfer to postsynaptic neurons.Brain Research 76, 526–30.
Schubert, P. andKreutzberg, G. W. (1976) Communication between the neuron and the vessels. InThe Cerebral Vessel Wall, (edited byCerv ós-Navarro, J.) pp. 207–213, New York: Raven Press.
Schubert, P., Rose, G., Lee, K., Lynch, G. andKreutzberg, G. W. (1977) Axonal release and transfer of nucleoside derivatives in the entorhinal-hippocampal system: an autoradiographic study.Brain Research 134, 347–52.
Schultz, J. andDaly, J. W. (1973) Cyclic adenosine 3′,5′-monophosphate in guinea pig cerebral cortical slices. I. Formation of cyclic adenosine 3′,5′-monophosphate from endogenous adenosine triphosphate and from radioactive adenosine triphosphate formed during a prior incubation with radioactive adenine.Journal of Biological Chemistry 248, 843–52.
Sjöstrand, J. (1965) Proliferative changes in glial cells during nerve regeneration.Zeitschrift für Zellforschung und mikroskopische Anatomie 68, 481–93.
Sjöstrand, J. (1966) Changes of nucleoside phosphatase activity in the hypoglossal nucleus during nerve regeneration.Acta physiologica scandinavica 67, 219–28.
Sumner, B. E. H. (1974) The nature of the dividing cells around axotomized hypoglossal neurones.Journal of Neuropathology and Experimental Neurology 33, 507–18.
Torvik, A. andSkjørten, F. (1971) Electron microscopic observations on nerve cell regeneration and degeneration after axon lesions. II. Changes in the glial cells.Acta neuropathologica (Berlin) 17, 265–82.
Uusitalo, R. J. andKarnovsky, M. H. (1977) Surface localization of 5′-nucleotidase on the mouse lymphocyte.Journal of Histochemistry and Cytochemistry 25, 87–96.
Watson, W. E. (1965) An autoradiographic study of the incorporation of nucleic-acid precursors by neurones and glia during nerve regeneration.Journal of Physiology 180, 741–53.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kreutzberg, G.W., Barron, K.D. 5′-Nucleotidase of microglial cells in the facial nucleus during axonal reaction. J Neurocytol 7, 601–610 (1978). https://doi.org/10.1007/BF01260892
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01260892