Summary
In rats continuously exposed to β,β′-iminodipropionitrile (IDPN) for long periods, numerous Schwann cell and oligodendrocyte ingrowths extending into giant axonal swellings were found. These ingrowths, cytoplasmic processes of the Schwann cells and oligodendrocytes which deeply indented the axon, regularly arose from Schmidt-Lanterman clefts in the internodes. They dissected along an intra-axonal ‘cleavage plane’ which separated the giant axonal swellings into two compartments: an inner central channel of relatively normal axoplasm and an outer ‘axoplasmic pad’ comprised of circularly or spirally-arranged masses of neurofilaments. Multiple ingrowths often arose within a single internode, resulting in nearly complete segregation of the axoplasmic pad from the central channel over long distances. At the interface between the two axoplasmic compartments, internal myelin sheaths were occasionally found. The distinctive ingrowths found in this study appear to represent unusual responses of the Schwann cells and oligodendrocytes to the primary neurofilamentous axonal pathology produced by IDPN.
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Allt, G. (1972) An ultrastructural analysis of remyelination following segmentai demyelination.Acta neuropathologica 22, 333–44.
Chou, S. M. &Hartmann, H. A. (1964) Axonal lesions and waltzing syndrome after IDPN administration in rats.Acta neuropathologica 3, 428–50.
Chou, S. M. &Hartmann, H. A. (1965) Electron microscopy of focal neuroaxonal lesions produced by β,β′-iminodipropionitrile (IDPN) in rats.Acta neuropathologica 4, 590–603.
Clark, A. W., Griffin, J. W. &Price, D. L. (1980) The axonal pathology in chronic IDPN intoxication.Journal of Neuropathology and Experimental Neurology 39, 42–55.
Ghabriel, M. N. &Allt, G. (1980a) Schmidt-Lanterman incisures. I. A quantitative teased fibre study of remyelinating peripheral nerve fibres.Acta neuropathologica 52, 85–95.
Ghabriel, M. N. &Allt, G. (1980b) Schmidt -Lanterman incisures, II. Light and electron microscope study of remyelinating peripheral nerve fibres.Acta neuropathologica 52, 97–104.
Griffin, J. W. &Price, D. L. (1980) Proximal axonopathies induced by toxic chemicals. InExperimental and clinical neurotoxicology (edited bySpencer, P. S. &Schaumburg, H. H.), pp. 161–78. Baltimore: Williams and Wilkins.
Griffin, J. W. &Price, D. L. (1981) Segmental demyelination in experimental IDPN and hexacarbon neuropathies: evidence for an axonal influence.Laboratory Investigation 45, 130–41.
Griffin, J. W., Hoffman, P. N., Clark, A. W., Carroll, P. T. &Price, D. L. (1978) Slow axonal transport of neurofilament proteins: impairment by β,β′-iminodipropionitrile administration.Science 202, 633–5.
Griffin, J. W., Price, D. L., Hoffman, P. N., Clark, A. W., Drachman, D. B. &Pestronk, A. (1979) Toxic axonal neuropathies. InCurrent topics in nerve and muscle research (edited byAguayo, A. &Karpati, G.), pp. 282–91, Amsterdam: Exerpta Medica.
Hall, S. M. (1973) Some aspects of remyelination after demyelination produced by the intraneural injection of lysophosphatidyl choline.Journal of Cell Science 13, 461–77.
Shimono, M., Izumi, K. &Kuroiwa, Y. (1978) 3,3′-iminodipropionitrile induced centrifugal segmental demyelination and onion bulb formation.Journal of Neuropathology and Experimental Neurology 37, 375.
Spencer, P. S. &Thomas, P. K. (1974) Ultra structural studies of the dying back process. II. The sequestration and removal by Schwann cells and oligodendrocytes of organelles from normal and diseased axons.Journal of Neurocytology 3, 763–83.
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Griffin, J.W., Price, D.L. Schwann cell and glial responses inβ,β ′-iminodipropionitrile intoxication. I. Schwann cell and oligodendrocyte ingrowths. J Neurocytol 10, 995–1007 (1981). https://doi.org/10.1007/BF01258526
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DOI: https://doi.org/10.1007/BF01258526