Summary
Viral type microvesicles and microscopic foci of epithelial necrosis were found in 10 different areas of grossly normal-appearing hairy skin of 17 steers experimentally inoculated with foot-and-mouth disease virus and necropsied 2 to 5 days after inoculation. Large quantities of virus were isolated from the epidermis of the respective body areas, and the microscopic skin lesions had most of the essential morphologic features of gross lesions caused by foot-and-mouth disease virus, at the usual sites of predilection in cattle. No comparable microscopic skin lesions were found in the uninoculated controls nor in several other inoculated steers necropsied at an early stage of infection. It was concluded that microscopic skin lesions may be a consistent pathologic alteration associated with foot-and-mouth disease virus infection.
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References
Armed Forces Institute of Pathology: Manual of Histologic and Special Staining Techniques. 2nd ed. New York: McGraw-Hill Book Co., Inc., 1960.
Bachrach, H. L., J. J. Callis, W. R. Hess, andR. E. Patty: A plaque assay for foot-and-mouth disease virus and kinetics of virus reproduction. Virology4, 224 (1957).
Cohrs, P.: Verschorfende, nicht Blasen bildende Form der Maul- und Klauenseuche. Dtsch. tierärztl. Wschr.48, 620 (1940).
Cottral, G. E., P. Gailiunas, andR. L. Campion: Detection of foot-and-mouth disease virus in lymph nodes of cattle throughout the course of infection. Proc. U.S. Livestock San. A. 463 (1964).
Cottral, G. E., R. E. Patty, P. Gailiunas, andR. W. Scott; Sensitivity of cell cultures, cattle, mice, and guinea pigs for detection of nineteen foot-and-mouth disease viruses. Bull. Off. int. Epiz.63, 1607 (1965).
Gailiunas, P., andG. E. Cottral: Presence and persistence of foot-and-mouth disease virus in bovine skin. J. Bact.91, 2333 (1966).
Gailiunas, P., G. E. Cottral, andH. R. Seibold: Teat lesions in heifers experimentally infected with foot-and-mouth disease virus. Amer. J. vet. Res.25, 1062 (1964).
Jubb, K. V. F., andP. C. Kennedy: Pathology of Domestic Animals. Vol. 2. New York and London: Academic Press, 1963.
Marek, J., R. Manninger undJ. Moscy: Spezielle Pathologie und Therapie der Haustiere. Vol. 1. 293. Jena: Gustav Fischer, 1945.
National Academy of Sciences: Studies on foot-and-mouth disease. National Research Council, Washington, D.C. 1966.
Nieberle, K., andP. Cohrs: Textbook of the special pathological anatomy of domestic animals. Oxford: Pergamon Press, 1967.
Platt, H.: Observations on the pathology of experimental foot-and-mouth disease in the adult guinea pig. J. Path. Bact.75, 119 (1958).
Platt, H.: The susceptibility of the skin and epidermoid mucous membranes to virus infection in man and other animals. Guy's Hosp. Rep.112, 479 (1963).
Scott, F. W., G. E. Cottral, andP. Gailiunas: Persistence of foot-and-mouth disease virus in external lesions and saliva of experimentally infected cattle. Amer. J. vet. Res.27, 1531 (1966).
Seibold, H. R.: A revised concept of the lingual lesions in cattle with foot-and-mouth disease. Amer. J. vet. Res.24, 1123 (1963).
Seibold, H. R., andJ. B. Sharp, Jr.: A revised concept of the pathologic changes of the tongue in cattle with vesicular stomatitis. Amer. J. vet. Res.21, 35 (1960).
Smith, H. A., andT. C. Jones: Veterinary Pathology. Philadelphia: Lea and Febiger, 1966.
Sutmöller, P., P. A. de Mello, M. N. Honigman, andK. E. Federer: Infectivity for cattle and pigs of three strains of foot-and-mouth disease virus isolated from carrier cattle. Amer. J. vet. Res.28, 101 (1967).
World Reference Laboratory, Pirbright: A revised list of subtype reference strains of the virus of foot-and-mouth disease held at the world reference laboratory, Pirbright, England. Bull. Off. int. Epiz.63, 1655 (1965).
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Gailiunas, P. Microscopic skin lesions in cattle with foot-and-mouth disease. Archiv f Virusforschung 25, 188–200 (1968). https://doi.org/10.1007/BF01258164
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DOI: https://doi.org/10.1007/BF01258164