Skip to main content

Advertisement

SpringerLink
Log in

The role of histamine receptors in the stimulation of gastric acid secretion

  • Original Articles
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

In conscious cats provided with chronic gastric fistulas, metiamide, an H2-receptor antagonist, when given intravenously in a dose of 12 μmol/kg-hr, strongly inhibited gastric acid output stimulated maximally with histamine, pentagastrin, caerulein, insulin, urecholine, and peptone meal. Atropine sulfate administered in a dose of 0.288 μmol/kg-hr also inhibited gastric response to all these stimulants except histamine. These results can be explained by the hypothesis of interaction of various receptors of parietal cells, might be regarded as evidence for histamine mediation in the physiological stimulation of parietal cells, or may suggest the nonselectivity of the action of metiamide on parietal cell receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. MacIntosh FC: Histamine as a normal stimulant of gastric secretion. Q J Exp Physiol 28:87, 1938

    Google Scholar 

  2. Black JW, Duncan WAM, Durant CJ, Ganellin CR, Parsons EM: Definition and antagonism of histamine H2-receptors. Nature 236:385, 1972

    PubMed  Google Scholar 

  3. Konturek SJ, Dubiel J: Effect of diversion of bile and pancreatic juice on pentagastrin produced duodenal ulcers in cats. Scand J Gastroenterol 4:59, 1969

    PubMed  Google Scholar 

  4. Fordtran JS, Walsh J: Gastric acid secretion rate and buffer content of the stomach after eating; results in normal subjects and in patients with duodenal ulcer. J Clin Invest 52:645, 1972

    Google Scholar 

  5. Snedecor GW, Cochran WG: Statistical Methods, Sixth Edition, Ames, Iowa State University Press, 1967

    Google Scholar 

  6. Grossman MI, Konturek SJ: Inhibition of acid secretion in dog by metiamide, a histamine antagonist acting on H2-receptors. Gastroenterology 66:517, 1974

    PubMed  Google Scholar 

  7. Code CF: Histamine and gastrin secretion; a later look, 1955–1965. Fed Proc 24:1311, 1965

    PubMed  Google Scholar 

  8. Johnson LR: Control of gastric secretion; no room for histamine. Gastroenterology 61:106, 1971

    PubMed  Google Scholar 

  9. Grossman MI: Gastrin, cholecystokinin and secretinact on one receptor. Lancet 1:1088, 1970

    PubMed  Google Scholar 

  10. Konturek SJ, Radecki T, Biernat J, Thor P: Effect of caerulein on pentagastrin-induced gastric acid secretion and peptic ulcers in cats. Scan J Gastroenterol 5:613, 1970

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Physiology, Medical Academy, ul. Grzegórzecka 16, Cracow, Poland

    Stanisław J. Konturek MD, Teresa Demitrescu MD & Tadeusz Radecki MD

Authors
  1. Stanisław J. Konturek MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Teresa Demitrescu MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tadeusz Radecki MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Konturek, S.J., Demitrescu, T. & Radecki, T. The role of histamine receptors in the stimulation of gastric acid secretion. Digest Dis Sci 19, 999–1006 (1974). https://doi.org/10.1007/BF01255781

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01255781

Keywords

Search

Navigation