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Stereoselectivity of spinal neurotransmission: Effects of baclofen enantiomers on tail-flick reflex in rats

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Summary

Spinal rats and rats with an intact neuraxis received an intrathecal injection of an enantiomer of baclofen. TheR-enantiomer was 100–1000 times more potent than its antipode in inhibiting the tail-flick reflex, both in intact rats and in spinal rats. Spinalization enhanced the inhibitory effects of both enantiomers without altering their dose-response relations. The findings show that baclofen enantiomers have direct actions on stereoselective spinal mechanisms and that spinalization fails to alter the stereoselectivity of spinal mechanisms towards the enantiomers.

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  1. D. F. Smith

    Present address: The Psychopharmacology Research Unit, Aarhus University Institute of Psychiatry, Psychiatric Hospital, Risskov, Denmark

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    Smith, D.F. Stereoselectivity of spinal neurotransmission: Effects of baclofen enantiomers on tail-flick reflex in rats. J. Neural Transmission 60, 63–67 (1984). https://doi.org/10.1007/BF01254766

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    • DOI: https://doi.org/10.1007/BF01254766

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