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Diurnal and seasonal variations in human platelet serotonin in man

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Summary

Platelet serotonin (5-HT) was found to be an individually constant parameter correlating with the uptake of exogenous 5-HT. A pronounced diurnal pattern of 5-HT, with a minimum in the afternoon and higher values in the morning and evening, was similar to the diurnal variations in plasma free tryptophan. Platelet 5-HT was significantly higher at 8 a.m. than 4 p.m. in spring but no longer in autumn, and was similar in both men and women. It appeared that peripheral diurnal variations in 5-HT were opposite in phase to the central 5-HT rhythm.

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  1. Anna Wirz-Justice

    Present address: Psychiatrische Universitätsklinik, Basel, Switzerland

Authors and Affiliations

  1. Psychiatrische Universitätsklinik, Basel, Switzerland

    M. Lichtsteiner & H. Feer

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  1. Anna Wirz-Justice
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  2. M. Lichtsteiner
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  3. H. Feer
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Wirz-Justice, A., Lichtsteiner, M. & Feer, H. Diurnal and seasonal variations in human platelet serotonin in man. J. Neural Transmission 41, 7–15 (1977). https://doi.org/10.1007/BF01252961

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  • DOI: https://doi.org/10.1007/BF01252961

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