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Excitatory effect of intrahippocampal injection of glutamic acid on rabbit EEG

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Summary

Glutamatic acid microinjection into the rabbit dorsal hippocampus was studied in its effects on hippocampal and cortical electroencephalogram (EEG). The studies were carried out on rabbits with chronically implanted electrodes and cannulae. Bipolar, siver recording electrodes and stainless steel cannulae were implanted into the hippocampus, and recording electrodes were placed on the surface of the frontal and cingular cortical areas. Low doses of glutamatic acid (5–25 nM) induced EEG and behavioral arousal. Short lasting epileptiform-like seizures and behavioral convulsions were induced after injection of high doses of glutamic acid (100–500 nM). These findings suggest that glutamic acid in the hippocampus of the rabbit is involved in behavioral arousal and epileptiform-like disorders.

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  1. A. Śmialowski

    Present address: Department of Neuropharmacology, Institute of Pharmacology Polish Academy of Sciences, Kraków-Bronowice, Poland

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    1. A. Śmialowski
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    Śmialowski, A. Excitatory effect of intrahippocampal injection of glutamic acid on rabbit EEG. J. Neural Transmission 58, 205–211 (1983). https://doi.org/10.1007/BF01252806

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    • DOI: https://doi.org/10.1007/BF01252806

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