Summary
Following right middle cerebral artery occlusion in the rat, striatal dopaminergic system alterations were studied. Dopamine turnover was assessed by measuring 3,4-dihydroxyphenylacetic acid concentrations and dopamine receptor function, by measuring (3H)-Spiroperidol binding. There was a transient decrease in 3,4-dihydroxyphenylacetic acid and permanent damage to dopamine receptors, as indicated by a time-dependent progressive reduction in the number of (3H)-Spiroperidol binding sites. The receptor deficit also manifested as turning behaviour towards the lesioned side 4 weeks after the lesion following subcutaneous apomorphine. Long-term changes of dopaminergic receptor activity in this experimental model of cerebral infarction may be secondary to cortical degeneration following middle cerebral artery occlusion.
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Materossi, C., Maoret, T., Rozzini, R. et al. Effect of right middle cerebral artery occlusion on striatal dopaminergic function. J. Neural Transmission 53, 257–264 (1982). https://doi.org/10.1007/BF01252037
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DOI: https://doi.org/10.1007/BF01252037