Summary
One postulated role of dopamine in the striatum is to reduce neuronal activity in cortico-striatal glutamergic terminals. We investigated the effects of methamphetamine, which displaces dopamine, on glutamate release from rat striatal slices. Methamphetamine significantly reduced K+-stimulated (45 mM) glutamate release. In slices prepared from rats treated 8 days previously with methamphetamine there was enhanced (approximately 200%) release of glutamate. This study demonstrates that dopamine has a modulatory effect on glutamate release in the striatum.
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Earle, M.L., Davies, J.A. The effect of methamphetamine on the release of glutamate from striatal slices. J. Neural Transmission 86, 217–222 (1991). https://doi.org/10.1007/BF01250707
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DOI: https://doi.org/10.1007/BF01250707