Summary
An endogenous feline C-type virus isolated from an SPF cat colony apparently free from FeLV and observed neoplasms, was found to be more closely related serologically to the RD114 virus than to conventional FeLV. It produced syncytia on a variety of cocultures, including a normal human lymphoid suspended cell culture. The endogenous C-type viral particles, while similar in overall size to FeLV, possessed nucleoids of significantly smaller size.
Similar content being viewed by others
References
Armstrong, D.: Multiple group-specific-antigen components of avian tumor viruses detected with chicken and hamster sera. J. Virol.3, 133–139 (1969).
August, T.: Personal communication, 1973.
Dougherty, E., andC. G. Rickard: Ultrastructural studies of feline leukemia virus. J. Ultrastruct. Res.32, 472–476 (1970).
Dougherty, R. M., andH. S. DiStephano: Virus particles associated with “nonproducer” Rous sarcoma cells. Virology27, 351–359 (1965).
Dougherty, R. M., andH. S. DiStephano: Lack of relationship between infection with avian leukosis virus and the presence of COFAL antigen in chick embryos. Virology29, 586–595 (1966).
Feller, U., R. M. Dougherty, andH. S. DiStephano: Comparative morphology of avian and murine leukemia viruses. J. nat. Cancer Inst.47, 1289–1298 (1971).
Hackett, A. J., A. Pfiester, andP. Arnstein: Biologic properties of a syncytiaforming agent isolated from domestic cats (feline syncytia-forming virus). Proc. Soc. exp. Biol. (N.Y.)135, 899–904 (1970).
Lowy, D. R., W. P. Rowe, N. Teich, andJ. W. Hartley: Murine leukemia virus: high frequency activationin vitro by 5-iododeoxyuridine and 5-bromodeoxyuridine. Science174, 155–156 (1971).
McAllister, R. M., M. Nicolson, M. B. Gardner, S. Rasheed, R. W. Rongey, W. D. Hardy, Jr., andR. V. Gilden: RD-114 virus compared with feline and murine type C viruses released from RD cells. Nature (New Biol.)242, 75–78 (1973).
Rabotti, G. F., andE. Blackham: Immunological determinants of avian sarcoma viruses: presence of group specific antibodies in fowl sera demonstrated by complement-fixation inhibition test. J. nat. Cancer Inst.44, 985–991 (1970).
Riggs, J. L., L. S. Oshiro, D. O. N. Taylor, andE. H. Lennette: Syncytium-forming agent isolated from domestic cats. Nature (Lond.)222, 1190–1191 (1969).
Schäfer, W., J. Lange, D. P. Bolognesi, F. Noronha, J. E. Post, andC. G. Rickard: Isolation and characterization of group-specific antigens from feline leukemia virus. Virology44, 73–82 (1971).
Stewart, S. E., G. Kasnic, Jr., C. Draycott, andT. Ben: Activation of viruses in human tumors by 5-iododeoxyuridine and dimethyl sulfoxide. Science175, 198–199 (1972).
Strand, M., andJ. T. August: Structural proteins of oncogenic ribonucleic acid virus. J. biol. Chem.248, 5627–5633 (1973).
Svoboda, J.: The tumorigenic action of Rous sarcoma in rats and the permanent production of Rous virus by the induced rat sarcoma XC. Folia biol. (Praha)7, 46–70 (1971).
Zeigel, R. F., G. H. Theilen, andM. J. Twiehaus: Electron microscopic observations on RE virus (Strain T) that induces reticuloendotheliosis in turkeys, chickens, and Japanese quail. J. nat. Cancer Inst.37, 709–729 (1966).
Zeigel, R. F., G. H.Theilen, and P.Sarma: Comparison of RE virus (Strain T) with the visceral lymphomatosis agent. Proc. elect. Microscopy Soc. Am., 25th Annual Meeting 114–115 (1969).
Author information
Authors and Affiliations
Additional information
This work was supported by Research Contract No. CP-33346 within the Virus Cancer Program of the National Cancer Institute, National Institutes of Health.
Rights and permissions
About this article
Cite this article
Noronha, F., Dougherty, E., Poco, A. et al. Cytological and serological studies of a feline endogenous C-type virus. Archiv f Virusforschung 45, 235–248 (1974). https://doi.org/10.1007/BF01249686
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01249686