Summary
The principal histologic features of monkey pox are cellular proliferation, degeneration, necrosis and inflammation. The major organ-systems affected are skin and mucous membranes, spleen, tonsils, lymph nodes, testis and ovary. Organs less frequently affected are kidney and pancreas. Focal accumulations of antigen were regularly revealed by fluorescent-antibody staining in tissues showing foci of necrosis, and yielding large concentrations of virus. Evidence is presented in support of specific viral injury. The pathogenesis of monkey pox is similar to other mammalian pox-infections and close particularly to variola in human beings.
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This investigation was supported by Public Health Service Research Grant AI 06263 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A.
Research Career Awardee No. K 6-AI-13976, National Institute of Allergy and Infectious Diseases, NIH.
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Wenner, H.A., Bolano, C.R., Cho, C.T. et al. Studies on the pathogenesis of monkey pox. Archiv f Virusforschung 27, 179–197 (1969). https://doi.org/10.1007/BF01249642
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DOI: https://doi.org/10.1007/BF01249642