Summary
8-OH-DPAT (0.25 mg/kg s.c.) produced a facilitation of the male rat sexual behavior, characterized by a decrease in the number of intromissions preceding ejaculation and in the time to ejaculation. This facilitation of the sexual behavior was antagonized by administration of the 5-HT and β-adrenoceptor antagonist pindolol (4mg/kg i.p.), but not by the selective β-adrenoceptor antagonist betaxolol (4 mg/kg i.p.). Neither pindolol (2–8 mg/kg), nor betaxolol (2–8 mg/kg), produced any statistically significant effects per se on the male rat sexual behavior, as observed here (mounts, intromissions, ejaculation latency or the post-ejaculatory interval). A higher dose (16mg/kg) of betaxolol produced a statistically significant reduction in the number of intromissions preceding ejaculation and in the ejaculation latency. The antagonism by pindolol of 8-OH-DPAT-induced effects on male rat sexual behavior suggests an involvement of 5-HT1A receptors in the facilitation of this behavior produced by 8-OH-DPAT.
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Ahlenius S, Larsson K (1984) Failure to antagonize the 8-hydroxy-2-(di-n-propylamino)tetralin-induced facilitation of male rat sexual behavior by the administration of 5-HT receptor antagonists. Eur J Pharmacol 99: 279–286
Ahlenius S, Larsson K (1985) Antagonism by lisuride and 8-OH-DPAT of 5-HTP-induced prolongation of performance of male rat sexual behavior. Eur J Pharmacol 110: 379–381
Ahlenius S, Larsson K (1987) Evidence for a unique pharmacological profile of 8-OH-DPAT by evaluation of its effects on male rat sexual behavior. In: Dourish CT, Ahlenius S, Hutson PH (eds) Brain 5-HT1A receptors. Ellis Horwood, Chichester, pp 185–198
Ahlenius S, Larsson K, Svensson L, Hjorth S, Carlsson A, Lindberg P, Wikström H, Sanchez D, Arvidsson L-E, Hacksell U, Nilsson JLG (1981) Effects of a new type of 5-HT receptor agonist on male rat sexual behavior. Pharmacol Biochem Behav 15: 785–792
Colino A, Halliwell JV (1987) Differential modulation of three separate K-conductances in hippocampal CA 1 neurons by serotonin. Nature 328: 73–77
Costain DW, Green AR (1978) β-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. Br J Pharmacol 64: 193–200
Dourish CT, Hutson PH, Curzon G (1986) Effects of 5-HT depletion and of 5-HT and catecholamine receptor antagonists on 8-OH-DPAT-induced feeding in the rat. Soc Neurosci Abstr 12: P1190
Engel J, Hjorth S, Svensson K, Carlsson A, Liljequist S (1984) Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur J Pharmacol 105: 365–368
Gerber R, Barbaz BJ, Martin LL, Neale R, Williams M, Liebman JM (1985) Antagonism of 1-5-hydroxytryptophan-induced head twitching in rats by lisuride: a mixed 5-hydroxytryptamine agonist-antagonist? Neurosci Lett 60: 207–213
Goodwin GM, Green AR (1985) A behavioural and biochemical study in mice and rats of putative agonists and antagonists for 5-HT1 and 5-HT2 receptors. Br J Pharmacol 84: 743–753
Green AR, Grahame-Smith DG (1976) (−)Propanolol inhibits the behavioural responses of rats to increased 5-hydroxytryptamine in the central nervous system. Nature 262: 594–596
Hjorth S, Carlsson A (1985) (−)Pindolol stereospecifically inhibits rat brain serotonin (5-HT) synthesis. Neuropharmacology 24: 1143–1146
Hjorth S, Carlsson A (1986) Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors? Eur J Pharmacol 129: 131–138
Hjorth S, Carlsson A, Lindberg P, Sanchez D, Wikström H, Arvidsson L-E, Hacksell U, Nilsson JLG (1982) 8-Hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity. J Neural Transm 55: 169–188
Kehr W, Neumeister R, Zimmerman R (1979) Action of ergot dopaminergic agonists on monoamine synthesis in rat brain. In: Fuxe K, Calne DB (eds) Dopaminergic ergot derivatives and motor function. Pergamon Press, Oxford, pp 173–186
Larsson K, Ahlenius S (1985) Masculine sexual behavior and brain monoamines. In: Segal M (ed) Psychopharmacology of sexual disorders. J Libbey, London, pp 15–32
Li CC (1964) Introduction to experimental statistics. McGraw-Hill, New York
Middlemiss DN, Fozard JR (1983) 8-Hydroxy-2-(di-n-propylamino)tetralin discriminates between subtypes of the 5-HT1 recognition site. Eur J Pharmacol 30: 151–153
Palacios JM, Pazos A, Hoyer D (1987) Characterization and mapping of 5-HT1A sites in the brain of animals and man. In: Dourish CT, Ahlenius S, Hutson PH (eds) Brain 5-HT1A receptors. Ellis Horwood, Chichester, pp 67–81
Renyi L (1987) The involvement of 5-HT1 and 5-HT2 receptors in different components of the 5-HT syndrome in the rat. Neuroscience S 22: 225 P
Siegel S (1956) Nonparametric statistics for the behavioral sciences. McGraw-Hill, New York
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Ahlenius, S., Larsson, K. Antagonism by pindolol, but not betaxolol, of 8-OH-DPAT-induced facilitation of male rat sexual behavior. J. Neural Transmission 77, 163–170 (1989). https://doi.org/10.1007/BF01248929
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DOI: https://doi.org/10.1007/BF01248929