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Dopamine-glutamate interactions in methamphetaminc-induced neurotoxicity

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Summary

Repeated administration of methamphetamine (m-AMPH) to rats induces dopamine (DA) terminal damage, and coadministration of antagonists of the N-methyl-D-aspartate (NMDA) or dopamine D1 or D2 receptors are protective. Striatal microdialysis of rats given a neurotoxic regimen of 4 × m-AMPH (4 mg/kg, s.c.) treatments revealed a dramatic and prolonged elevation of extracellular DA after the final m-AMPH administration. Neuroprotective regimens of MK-801, SCH 23390, or eticlopride greatly attenuated the overflow of DA resulting from the fourth m-AMPH treatment. By itself, MK-801 had no significant influence on striatal DA overflow, whereas either DA antagonist given alone elevated dialysate DA concentrations. A significant correlation was found between the magnitude of the m-AMPH-induced DA overflow of individual microdialyzed rats and their striatal DA content at sacrifice one week later.

We conclude that the ability of non-competitive NMDA antagonists and of the D1 or D2 antagonists to protect against m-AMPH-induced striatal DA terminal injury can be accounted for by their attenuation of m-AMPH-evoked DA overflow. These findings underscore the important role played by elevated extracellular DA concentrations to the injurious effects of this stimulant drug.

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  1. J. F. Marshall

    Present address: Department of Psychobiology, University of California, Irvine, CA, USA

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  1. Department of Psychobiology, University of California, Irvine, CA, USA

    S. J. O'Dell & F. B. Weihmuller

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Marshall, J.F., O'Dell, S.J. & Weihmuller, F.B. Dopamine-glutamate interactions in methamphetaminc-induced neurotoxicity. J. Neural Transmission 91, 241–254 (1993). https://doi.org/10.1007/BF01245234

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  • DOI: https://doi.org/10.1007/BF01245234

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