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Suppression of conditioned avoidance by 8-OH-DPAT in the rat

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Summary

Rats were trained to perform an aversely motivated discriminative task in a shuttle-box. The conditioned avoidance response was selectively suppressed by 8-OH-DPAT in a dose-dependent manner (25–100 μg·kg−1). There were no statistically significant deficits in discriminative performance. The present results suggest antipsychotic-like properties of 8-OH-DPAT.

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Author notes

  1. S. Ahlenius

    Present address: Department of Neuropharmacology, Astra Research Centre, Södertälje, Sweden

Authors and Affiliations

  1. Department of Psychology, University of Stockholm, Stockholm

    Marie -Louise Wadenberg

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  1. Marie -Louise Wadenberg
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  2. S. Ahlenius
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Wadenberg, M.L., Ahlenius, S. Suppression of conditioned avoidance by 8-OH-DPAT in the rat. J. Neural Transmission 74, 195–198 (1988). https://doi.org/10.1007/BF01244785

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  • DOI: https://doi.org/10.1007/BF01244785

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