Summary
The effects of short-term lithium administration on tryptophan levels and 5-hydroxytryptamine (5-HT) synthesis in whole brain and brain regions in rats were studied. Short-term lithium administration was found to increase whole brain tryptophan levels without affecting whole brain 5-HT synthesis. However, the increase of tryptophan varied between various brain regions, which may possibly be due to differences in the synaptosomal uptake of tryptophan between brain regions. In the striatum, where the tryptophan increase was most pronounced, an increase in 5-HT synthesis was found too. These latter findings suggest that the increase in 5-HT synthesis might be due to an increase in tryptophan availability.
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References
Atack C, Lindqvist M (1973) Conjoint native and ortophtaldialdehyde condensate assays for the fluorimetric determination of 5-hydroxyindoles in brain. Naunyn Schmiedebergs Arch Pharmacol 279: 267–284
Atack C, Magnusson T (1970) Individual elution of noradrenaline (together with adrenaline), dopamine, 5-hydroxytryptamine and histamine by means of mineral acid-organic solvent mixtures. J Pharm Pharmacol 22: 615–627
Bédard P, Carlsson A, Lindqvist M (1972) Effect of a transverse cerebral hemisection on 5-hydroxytryptamine metabolism in the rat brain. Naunyn Schmiedebergs Arch, Pharmacol 272: 1–15
Berggren U (1985 a) The effect of acute lithium administration on brain monoamine synthesis and the precursor amino acids tyrosine and tryptophan in brain and plasma in rats. J Neural Transm 61: 175–181
Berggren U (1985 b) Effects of chronic lithium treatment on brain monoamine metabolism and amphetamine-induced locomotor stimulation in rats. J Neural Transm 64: 239–250
Carlsson A, Davies JN, Kehr W, Lindqvist M, Atack C (1972) Simultaneous measurements of tyrosine and tryptophan hydroxylase activities in brainin vivo using an inhibitor of aromatic amino acid decarboxylase. Naunyn Schmiedebergs Arch Pharmacol 275: 153–168
Carlsson A, Lindqvist M (1978) Dependence of 5-HT and catecholamine synthesis on concentrations of precursor amino acids in rat brain. Naunyn Schmiedebergs Arch Pharmacol 303: 157–164
Fernstrom JD, Wurtman RJ (1972) Brain serotonin content: physiological regulation by plasma neutral amino acids. Science 178: 414–416
Grahame-Smith DG, Green AR (1974) The role of brain 5-hydroxytryptamine in the hyperactivity produced in rats by lithium and monoamine oxidase inhibition. Br J Pharmacol 52: 19–26
Kehr W, Carlsson A, Lindqvist M (1972) A method for the determination of 3,4-dihydroxyphenylalanine (DOPA) in brain. Naunyn Schmiedebergs Arch Pharmacol 274: 273–280
Knott PJ, Curzon G (1974) Effect of increased brain tryptophan on 5-hydroxytryptamine and 5-hydroxyindolyl acetic acid in the hypothalamus and other brain regions. J Neurochem 22: 1065–1071
Leighton W, Rosenblatt S, Chanley JD (1983) Lithium-induced changes in plasma amino acid levels during treatment of affective disorders. Psychiatry Res 8: 33–40
Mackenzie RG, Trulson ME (1978) Regional accumulation of tryptophan and serotonin metabolism following tryptophan loading in diabetic rats. J Neurochem 31: 157–160
Müller-Oerlinghausen B (1985) Lithium long-term treatment-does it act via serotonin? Pharmacopsychiatria 18: 214–217
Perez-Cruet J, Tagliamonte A, Tagliamonte P, Gessa GL (1971) Stimulation of serotonin synthesis by lithium. J Pharmacol Exp Ther 178: 325–330
Poitou P, Guerinot F, Bohuon C (1974) Effect of lithium on central metabolism of 5-hydroxytryptamine. Psychopharmacologia 38: 75–80
Schou M (1968) Lithium in psychiatric therapy and prophylaxis. J Psychiatry Res 6: 67–95
Schubert J (1973) Effect of chronic lithium treatment on monoamine metabolism in rat brain. Psychopharmacologia 32: 301–311
Sheard MH, Aghajanian GK (1970) Neuronally activated metabolism of brain serotonin: effect of lithium. Life Sci 9: 285–290
Swann A, Heninger G, Roth R, Maas J (1981) Differential effects of short and long term lithium on tryptophan uptake and serotonergic function in cat brain. Life Sci 28: 347–354
Wurtman RJ, Hefti F, Melamed E (1981) Precursor control of neurotransmitter synthesis. Pharmacol Rev 32: 315–335
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Berggren, U. Effects of short-term lithium administration on tryptophan levels and 5-hydroxytryptamine synthesis in whole brain and brain regions in rats. J. Neural Transmission 69, 115–121 (1987). https://doi.org/10.1007/BF01244102
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DOI: https://doi.org/10.1007/BF01244102