Abstract
Critical micelle concentrations (CMC) of sodium salts of cholic, deoxycholic and chenodeoxycholic acids in phosphate buffer (pH 7.92) have been determined from microcalorimetric titration curves. The obtained values of 18.4±0.6, 5.3±0.2 and 7.0±0.2 mM, respectively, for Na cholate, Na deoxycholate and Na chenodeoxycholate are close to literature values obtained by other methods. CMC values for ‘secondary’ micelles were also obtained. This microcalorimetric titration method gives highly reproducible results and rapid determination of CMC values of bile acid salts.
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Simonović, B.R., Momirović, M. Determination of critical micelle concentration of bile acid salts by micro-calorimetric titration. Mikrochim Acta 127, 101–104 (1997). https://doi.org/10.1007/BF01243172
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DOI: https://doi.org/10.1007/BF01243172