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Studies on virus-induced interferons produced by the human amniotic membrane and white blood cells

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Summary

Newcastle disease virus (NDV) induces in the human amniotic membrane (HAM) two interferons: a large amount of a heavy component (MW≥160,000) and a small amount of a light one (MW ranging from 22,000 to 25,000). The crude preparation and the interferon components induce the antiviral state in monkey cells (BSC-1) and in rat embryonic fibroblasts (REF).

In this study, HAM interferon is compared to the human interferon produced by white blood cells (WBC). Two fundamental differences are reported between these two types of interferon: (1) HAM interferon induces the antiviral state in REF, while WBC interferon is nearly inactive; (2) antibody produced against WBC interferon in rabbits does not neutralize the antiviral effect of HAM interferon.

Because of the fundamental differences observed in their antigenic structure and antiviral action, further study is necessary to investigate in more detail the mode of action of the two types of interferon.

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Author notes

  1. P. Duc-Goiran

    Present address: Institut National de la Santé et de la Recherche Médicale, Groupe de Recherches sur les Virus, HÔpital St.-Vincent-de-Paul, Paris, France

Authors and Affiliations

  1. Institut National de la Santé et de la Recherche Médicale, Groupe de Recherches sur les Virus, HÔpital St.-Vincent-de-Paul, Paris, France

    B. Galliot & C. Chany

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  1. P. Duc-Goiran
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  2. B. Galliot
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  3. C. Chany
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Duc-Goiran, P., Galliot, B. & Chany, C. Studies on virus-induced interferons produced by the human amniotic membrane and white blood cells. Archiv f Virusforschung 34, 232–243 (1971). https://doi.org/10.1007/BF01242997

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  • DOI: https://doi.org/10.1007/BF01242997

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