Summary
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1.
Susceptible and immunized cattle were exposed to FMDV in varying amounts, and by different routes, and a high percentage of cattle became carriers after pharyngeal or nasal exposure.
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2.
The percentage of virus “takes” was not altered appreciably by the immune status of the cattle; however, as could be expected, the susceptible cattle more often became clinically ill.
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3.
If only minimal amounts of virus were inoculated, carriers were sometimes produced without overt disease. In immune cattle, this direct establishment of asymptomatic carriers appeared to be the rule.
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4.
In immunized cattle, the number of virus “takes” was somewhat reduced when low doses of virus were inoculated by the pharyngeal or nasal route.
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5.
If the virus was able to establish itself in the pharynx of immunized cattle, active virus multiplication took place in spite of preinfection serum antibody and the absence of clinical signs.
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Sutmoller, P., McVicar, J.W. & Cottral, G.E. The epizootiological importance of foot-and-mouth disease carriers. Archiv f Virusforschung 23, 227–235 (1968). https://doi.org/10.1007/BF01241895
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DOI: https://doi.org/10.1007/BF01241895