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Influence of an arbovirus infection (Sindbis virus) on the protein and ribonucleic acid synthesis of cultivated chick embryo cells

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Summary

Cultured chick embryo cells infected with a group A arbovirus (Sindbis) showed a decreased synthesis of protein and RNA. Protein synthesis was more markedly depressed than RNA synthesis. Inhibition of protein synthesis started 1 to 1 1/2 hours after infection, and cup to 50 per cent inhibition occurred 6 hours postinfection. Results obtained by using p-fluorophenylalanine, actinomycin D and an interferon preparation suggest that the inhibition of cellular protein synthesis depends on the production of protein(s) coded by the viral genome.

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Author notes

  1. M. Mussgay

    Present address: Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen, BRD

  2. J. Horst

    Present address: Max-Planck-Institut für Biochemie, München, BRD

Authors and Affiliations

  1. Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen, BRD

    P. -J. Enzmann & J. Horst

Authors
  1. M. Mussgay
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  2. P. -J. Enzmann
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  3. J. Horst
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Dedicated to Prof. Dr. Dr. C.Hallauer on the occasion of his 70th birthday.

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Mussgay, M., Enzmann, P.J. & Horst, J. Influence of an arbovirus infection (Sindbis virus) on the protein and ribonucleic acid synthesis of cultivated chick embryo cells. Archiv f Virusforschung 31, 81–92 (1970). https://doi.org/10.1007/BF01241668

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  • DOI: https://doi.org/10.1007/BF01241668

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