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Primary effects of the rubella virus on the metabolism of BHK-21 cells grown in suspension cultures

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Summary

In BHK-21/13 S cells infected with rubella virus an early modification of the cellular metabolism was noted. Changes included a 12% increase in the level of respiration and a 50% increase in lactic acid production. Alanine synthesis was also strongly stimulated. Such changes were seen with infective virus but not with UV-inactivated virus.

These early changes were not apparent two to five hours after the viral infection, but reappeared at about the eighth hour and became more marked at the time of the virus release.

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Author notes

  1. Michèle Henry

    Present address: Laboratoire de Virologie, Bacteriologie, Immunologie, Faculté Mixte de Médecine et de Pharmacie, 8, Avenue Rockefeller, F-69 Lyon 8e, France

Authors and Affiliations

  1. Laboratoire de Chimie biologique, 43, Bd. du Onze Novembre 1918, F-69 Villeurbanne, France

    Gilbert Bardeletti & Danièle Gautheron

  2. Laboratoire de Virologie, Bacteriologie, Immunologie, Faculté Mixte de Médecine et de Pharmacie, 8, Avenue Rockefeller, F-69 Lyon 8e, France

    Roger Sohier

Authors
  1. Gilbert Bardeletti
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  2. Michèle Henry
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  3. Roger Sohier
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  4. Danièle Gautheron
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Bardeletti, G., Henry, M., Sohier, R. et al. Primary effects of the rubella virus on the metabolism of BHK-21 cells grown in suspension cultures. Archiv f Virusforschung 39, 26–34 (1972). https://doi.org/10.1007/BF01241526

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  • DOI: https://doi.org/10.1007/BF01241526

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