Skip to main content
SpringerLink
Log in

Viral replication in mouse macrophages

  • Published:
Archiv für die gesamte Virusforschung Aims and scope Submit manuscript

Summary

Cultures of mouse peritoneal macrophages were capable of supporting the growth of vesicular stomatitis virus (VSV), mengovirus, mouse hepatitis virus (MHV-3 and MHV-S), and reovirus type 3. Age of the cultures and peritoneal stimulation of macrophages appeared to influence this capacity. Increased viral replication was found in cultures one or more days old and in cultures of stimulated macrophages. Phytohemagglutinin (PHA)-stimulated mouse lymphocytes were relatively resistant; only VSV and mengovirus were capable of replicating in these cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Epstein, L. B., M. J. Cline, andT. C. Merigan: The interaction of human macrophages and lymphocytes in the phytohemagglutinin-stimulated production of inter feron. J. clin. Invest.50, 744–753 (1971).

    Google Scholar 

  2. Eustatia, J. M., andJ. van der Veen: Viral replication in cultures of phytohemagglutinin-treated mouse lymphocytes. Proc. Soc. exp. Biol. (N. Y.)137, 424–428 (1971).

    Google Scholar 

  3. Gallily, R., A. Warwick, andF. B. Bang: Ontogeny of macrophage resistance to mouse hepatitisin vivo andin vitro. J. exp. Med.125, 537–548 (1967).

    Google Scholar 

  4. Kärber, G.: Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak.162, 480–487 (1931).

    Google Scholar 

  5. Mallucci, L.: Effect of chloroquine on lysosomes and on growth of mouse hepatitis virus (MHV-3). Virology28, 355–362 (1966).

    Google Scholar 

  6. Shif, I., andF. B. Bang:In vitro interaction of mouse hepatitis virus and macrophages from genetically resistant mice. II. Biological characterization of a variant vims MHV (C3H) isolated from stocks of MHV (PRI). J. exp. Med.131, 851–862 (1970).

    Google Scholar 

  7. Silverstein, S.: Macrophages and viral immunity. Semin. Hematol.7, 185–214 (1970).

    Google Scholar 

  8. Smith, T. J., andR. R. Wagner: Rabbit macrophage interferons. I. Conditions for biosynthesis by virus-infected and uninfected cells. J. exp. Med.125, 559–577 (1967).

    Google Scholar 

  9. Wheelock, E. F.: Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin. Science149, 310–311 (1965).

    Google Scholar 

Download references

Author information

Author notes

  1. J. van der Veen

    Present address: Department of Medical Microbiology, University of Nijmegen, Nijmegen, The Netherlands

Authors and Affiliations

  1. Department of Medical Microbiology, University of Nijmegen, Nijmegen, The Netherlands

    J. M. Eustatia, E. Maase & P. van Helden

Authors
  1. J. M. Eustatia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Maase
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. van Helden
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. van der Veen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Eustatia, J.M., Maase, E., van Helden, P. et al. Viral replication in mouse macrophages. Archiv f Virusforschung 39, 376–380 (1972). https://doi.org/10.1007/BF01241017

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01241017

Keywords

Search

Navigation