Summary
The South African vervet monkey virus SA11 and the 0 agent isolated from abattoir waste are enteric viruses related serologically and with a number of other properties in common. They grow well in VMK cells in which they produce discrete round or oval cytoplasmic inclusions. These viruses can be distinguished from reoviruses by their cytopathic effect, by their failure to agglutinate human group 0 erythrocytes, and by the inability of antisera against the reovirus prototype strains to neutralize these two agents to a significant titre. They differ from enteroviruses in the changes with they induce in tissue cultures, and by their relative instability at pH3 and at 50°C in the presence of molar magnesium chloride; but they are resistant to sodium deoxycholate. SA11 is resistant to ether and chloroform, but the 0 agent suffers loss of titre in the presence of these lipid solvents although infectivity is not entirely destroyed within 24 hours.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Andrewes, C. H., andD. M. Horstmann: The susceptibility of viruses to ethyl ether. J. gen. Microbiol.3, 290 (1949).
Black, F. L.: Relationship between virus particle size and filterability through gradocol membranes. Virology5, 391 (1958).
Cooney, M. K., L. C. McLaren, andH. Bauer: A newly-recognized enterovirus, with affinity for primary human amnion cells, isolated from cases of aseptic meningitis. Amer. J. Hyg.75, 301 (1962).
Feldman, H. A., andS. S. Wang: Sensitivity of various viruses to chloroform. Proc. Soc. exp. Biol. (N.Y.)106, 736 (1961).
Hamparian, V. V., M. R. Hilleman, andA. Ketler: Contributions to characterization and classification of animal viruses. Proc. Soc. exp. Biol. (N.Y.)112, 1040 (1963).
Ketler, A., V. V. Hamparian, andM. R. Hilleman: Characterization and classification of ECHO 28 — rhinovirus — coryzavirus agents. Proc. Soc. exp. Biol. (N.Y.)110, 821 (1962).
Hull, R. N., J. R. Minner, andJ. W. Smith: New viral agents recovered from tissue cultures of monkey kidney cells. Amer. J. Hyg.63, 204 (1956).
Lennette, E. H.: General principles underlying laboratory diagnosis of viral and rickettsial infections. In: Lennette, E. H., and N. J. Schmidt (Edit.), Diagnostic Procedures for Viral and Rickettsial Diseases, p. 48. New York: Amer. publ. Hlth. Ass. Inc. (1964).
Malherbe, H., andR. Harwin: Seven viruses isolated from the vervet monkey. Brit. J. exp. Path.38, 539 (1957).
Malherbe, H., R. Harwin, andM. Ulrich: The cytopathic effects of vervet monkey viruses. S. Afr. med. J.37, 407 (1963).
Malherbe, H., M. Strickland-Cholmley, andS. M. Geyer: Viruses in abattoir waste. In: Berg, G. (Edit.), Transmission of Viruses by the Water Route. New York: John Wiley and Sons (1967).
Malherbe, H.; Cytoplasmic inclusions in neurones of cercopithecus monkeys. Nature (Lond.)209, 832 (1966).
Reed, L. J., andH. Muench: A simple method of estimating fifty per cent endpoints. Amer. J. Hyg.27, 493 (1938).
Rosen, L.: Reoviruses. In: Lennette, E. H., and N. J. Schmidt (Edit.), Diagnostic Procedures for Viral and Rickettsial Diseases, p. 259. New York: Amer. publ. Hlth. Assoc. Inc. (1964).
Salzman, N. P.: The rate of formation of vaccinia deoxyribonucleic acid and vaccinia virus. Virology10, 150 (1960).
Vogel, J., andA. Shelokov: Adsorption-hemagglutination test for influenza virus in monkey kidney tissue culture. Science126, 358 (1957).
Wallis, C., andJ. L. Melnick: Cationic stabilization — a new property of enteroviruses. Virology16, 504 (1962).
Author information
Authors and Affiliations
Additional information
Dedicated to ProfessorJohn F. Enders on the occasion of his 70th birthday.
Rights and permissions
About this article
Cite this article
Malherbe, H.H., Strickland-Cholmley, M. Simian virus SA11 and the related 0 agent. Archiv f Virusforschung 22, 235–245 (1967). https://doi.org/10.1007/BF01240518
Issue Date:
DOI: https://doi.org/10.1007/BF01240518