Summary
Morphologic studies were performed in “Wellesley Hybrid” and commercial laboratory mice fed synthetic chow of two types. The pancreatic islets of diabetic animals of both groups were greatly enlarged, and were composed almost exclusively of beta cells actively synthesizing insulin. The islets of the non-diabetic mice were normal. There was excellent correlation between the presence of diabetes, the level of serum TRI and islet morphology regardless of mouse strain and dietary regimen.
Résumé
Nous avons étudié la morphologie des îlots de Langerhans de souris hybrides de Wellesley (C3HfxI) et de souris albinos ordinaires soumises à deux régimes synthétiques de laboratoire. Nous avons observé une forte augmentation du volume des îlots de Langerhans des animaux diabétiques soumis aux deux types de régime, ces îlots étant composés presque exclusivement de cellules B actives. L'apparence des îlots de Langerhans d'animaux non-diabétiques était normale. Il existe chez ces animaux une excellente corrélation entre la présence de diabète, les taux d'insuline immunoréactive sérique, et l'apparence des îlots, ceci pour les deux régimes.
Zusammenfassung
An “Wellesley Hybrid” und normalen Laboratoriumsmäusen, denen zwei verschiedene Arten von synthetischem Futter gegeben worden war, wurden morphologische Studien durchgeführt. Die Langerhans'schen Inseln diabetischer Tiere beider Gruppen waren stark vergrößert und bestanden beinahe ausschließlich aus aktiv Insulin synthetisierendenβ-Zellen. Die Inseln der nicht-diabetischen Mäuse waren normal. Es bestand ein deutlicher Zusammenhang zwischen dem Vorhandensein von Diabetes, dem immunreaktiven Insulin Spiegel im Serum und der Inselmorphologie, unabhängig von Mäusestamm und Diät.
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Supported in part by grants from the United States Public Health Service, AM-09584-02, T1-AM-05077-10, 5 ROI CA-07726-03.
Paper III of this series isGleason et. al., 1967.
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Like, A.A., Jones, E.E. Studies on experimental diabetes in the Wellesley Hybrid mouse. Diabetologia 3, 179–187 (1967). https://doi.org/10.1007/BF01222196
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DOI: https://doi.org/10.1007/BF01222196