Patient factors that predict failure of omeprazole, clarithromycin, and tinidazole to eradicateHelicobacter pylori

Abstract

Omeprazole (20mg od/b.d.), clarithromycin (250mg b.d.) and tinidazole (500mg b.d. for 7 days) [OCT] is an effective regimen againstHelicobacter pylori. However, treatment fails in 5%–10% of patients and the reasons for this are not clear. We investigated patient factors that independently predicted failure of this regimen.H. pylori-positive patients were prescribed OCT and the success of treatment was evaluated by the¹³C-urea breath test at least 4 weeks after completion of therapy. Patients were prospectively interviewed on past medical history of peptic ulcer and H₂-receptor antagonist (H₂RA) pre-treatment, smoking history, and alcohol intake. Data were also collected on age, gender, and endoscopic diagnosis to determine factors predicting failure of OCT.H. pylori eradication was achieved in 238 of 273 patients [87%–95% confidence intervals (CI), 83%–91%]. Age, alcohol intake, past medical history of peptic ulcer and peptic ulcer at endoscopy were not independently associated with treatment failure.H. pylori eradication with OCT was less successful in women (P=0.02), in patients who had received H₂RA pre-treatment (P=0.02), and in smokers (P=0.02) when evaluated by multiple logistic regression. These findings indicate that OCT is less effective in smokers and in patients who receive H₂RA pre-treatment suggesting that these agents should be avoided, if possible, before the patient commences therapy.H. pylori eradication was less successful in women; this result needs further evaluation.