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Cyclosporin A enhances locoregional metastasis of the CC531 rat colon tumour

  • Original Paper
  • Experimental Oncology
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Abstract

The immunosuppressive drug cyclosporin A has been evaluated recently in phase II trials in cancer therapy as a reverter of P-glycoprotein-mediated multidrug resistance. As an immunosuppressive agent, cyclosporin A potentially can enhance tumour growth. We investigated this potency of cyclosporin A in the weakly immunogenic CC531 colon adenocarcinoma model, using the same dose that had previously been shown to intensify the antitumour activity of doxorubicin in vivo. In vitro cyclosporin A caused no growth acceleration and only in high doses was growth inhibition of CC531 cells observed. In vivo no evidence of growth enhancement was found in short-term assays but, after 4 weeks, rats treated with cyclosporin A had a significantly higher tumour load, mainly consisting of locoregional metastases. These experiments in the CC531 tumour model show that cyclosporin A, used as a reverter of multidrug resistance, may produce short-term improvement of antitumour activity but may also induce enhancement of tumour metastasis.

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Abbreviations

MDR :

multidrug resistance

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Authors and Affiliations

  1. Department of Surgical Oncology, Rotterdam Cancer Institute, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands

    W. Van de Vrie & A. M. M. Eggermont

  2. Laboratory for Experimental Surgery, Erasmus University, PO Box 1738, 3000 DR, Rotterdam, The Netherlands

    W. Van de Vrie, R. L. Marquet & A. M. M. Eggermont

Authors
  1. W. Van de Vrie
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  2. R. L. Marquet
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  3. A. M. M. Eggermont
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Van de Vrie, W., Marquet, R.L. & Eggermont, A.M.M. Cyclosporin A enhances locoregional metastasis of the CC531 rat colon tumour. J Cancer Res Clin Oncol 123, 21–24 (1997). https://doi.org/10.1007/BF01212610

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  • DOI: https://doi.org/10.1007/BF01212610

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