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Endosomes, receptor tyrosine kinase internalization and signal transduction

  • Intracellular Traffic
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Bioscience Reports

Abstract

Upon the binding of insulin or epidermal growth factor to their cognate receptors on the liver parenchymal plasmalemma, signal transduction and receptor internalization are near co-incident. Indeed, the rapidity and extent; of ligand mediated receptor internalization into endosomes in liver as well as other organs predicts that signal transduction is regulated at this intracellular locus. Although internalization has been thought as a mechanism to attenuate ligand mediated signal transduction responses, detailed studies of internalized receptors in isolated liver endosomes suggest an alternative scenario whereby selective signal transduction pathways can be accessed at this locus.

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Authors and Affiliations

  1. Departments of Anatomy and Cell Biology, McGill University, H3A 2B2, Montreal, P.Q., Canada

    John J. M. Bergeron & Patricia C. Baass

  2. Department of Biochemistry, McGill University, H3A 2B2, Montreal, P.Q., Canada

    John J. M. Bergeron & G. M. Di Guglielmo

  3. Department of Medicine, McGill University, H3A 2B2, Montreal, P.Q., Canada

    John J. M. Bergeron & Barry I. Posner

  4. INSERM U30, Hôpital des Enfants Malades, Paris, France

    François Authier

Authors
  1. John J. M. Bergeron
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  2. G. M. Di Guglielmo
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  3. Patricia C. Baass
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  4. François Authier
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  5. Barry I. Posner
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Bergeron, J.J.M., Di Guglielmo, G.M., Baass, P.C. et al. Endosomes, receptor tyrosine kinase internalization and signal transduction. Biosci Rep 15, 411–418 (1995). https://doi.org/10.1007/BF01204345

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  • DOI: https://doi.org/10.1007/BF01204345

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