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Ovarian hyperstimulation syndrome: A review of pathophysiology

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References

  1. Rabau E, David A, Serr DM, Mashiach S, Lunenfeld B: Human menopausal gonadotropins for anovulation and sterily. Results of 7 years of treatment. Am J Obstet Gynecol 1967;96:92–98

    Google Scholar 

  2. Schenker JG, Weinstein D: Ovarian hyperstimulation syndrome: A current survey. Fertil Steril 1978;30:255–268

    PubMed  Google Scholar 

  3. Balasch J, Carmona F, Llach J, Arroyo V, Jove I, Vanerell JA: Acute prerenal failure and liver dysfunction in a patient with severe ovarian hyperstimulation syndrome. Hum Reprod 1990;5:348–351

    PubMed  Google Scholar 

  4. Younis JS, Zeevi D, Rabinowitz R, Laufer N, Schenker JG: Transient liver function test abnormalities of ovarian hyperstimulation syndrome. Fertil Steril 1988;50:176–178

    PubMed  Google Scholar 

  5. Rizk B, Meagher S, Fisher A: Severe ovarian hyperstimulation syndrome and cerebrovascular accidents. Hum Reprod 1990;5:697–698

    PubMed  Google Scholar 

  6. Padilla SL, Zamaria S, Baramki TA, Garcia JE: Abdominal paracentesis for the ovarian hyperstimulation syndrome with severe pulmonary compromise. Fertil Steril 1990;53:365–367

    PubMed  Google Scholar 

  7. Moses M, Bogowsky H, Anteby E,et al. Thromboembolic phenomena after ovarian stimulation with human menopausal gonadotropins. Lancet 1965;2:1213–1215

    PubMed  Google Scholar 

  8. Crooke AC, Butt WR, Carrington SP,et al. Pregnancy in women with secondary amenorrhea treated with human gonadotropins. Lancet 1964;1:184–188

    Google Scholar 

  9. Polishuk WZ, Schenker JG: Ovarian overstimulation syndrome. Fertil Steril 1969;20:443–450

    PubMed  Google Scholar 

  10. Navot D, Relou A, Birkenfeld A, Rabinowitz R, Brzezinski A, Margalioth EJ: Risk factors and prognostic variables in the ovarian hyperstimulation syndrome. Am J Obstet Gynecol 1988;159:210–215

    PubMed  Google Scholar 

  11. Navot D, Bergh PA, Laufer N: Ovarian hyperstimulation syndrome in novel reproductive technologies: Prevention and treatment. Fertil Steril 1992;58:249–261

    PubMed  Google Scholar 

  12. Haning RV Jr, Boehnlein LM, Carlson IH, Kuzman DL, Zweibel WJ: Diagnosis-specific serum 17 beta-estradiol (E2) upper limits for treatment with menotropins using a 125-I directed E2 assay. Fertil Steril 1984;42:882–889

    PubMed  Google Scholar 

  13. Golan A, Ron-El, Herman A, Soffer Y, Weinraub Z, Caspi E: Ovarian hyperstimulation syndrome: An update review. Obstet Gynecol Surv 1989;6:430–440

    Google Scholar 

  14. Blankenstein J, Mashiach S, Lunenfeld B: Induction of ovulation with gonadotropins.In Induction of Ovulation and In Vitro Fertilization, J Blankenstein, S Mashiach, B Lunenfeld (eds). Chicago, Yearbook Medical, 1986, p 122

    Google Scholar 

  15. Tal J, Paz B, Samberg I, Lazarov N, Sharf M: Ultrasonographic and clinical correlates of menotropins versus sequential clomiphene citrate: Menotropin therapy for induction of ovulation. Fertil Steril 1985;44:342–349

    PubMed  Google Scholar 

  16. Blankenstein J, Shavel J, Saadon T, Kukia EE, Rabinivici J, Pariente C, Lunenfeld B, Serr DM, Mashiach S: Ovarian hyperstimulation syndrome: Prediction by number and size of preovulatory ovarian follicles. Fertil Steril 1987;47:597–602

    PubMed  Google Scholar 

  17. Bryce RL, Picker RH, Saunders DM: Ultrasound in gonadotropin therapy: A better predictor of ovarian hyperstimulation? Aust NZ J Obstet Gynecol 1981;21:237–239

    Google Scholar 

  18. Lunenfeld B, Insler V: Gonadotropins.In Diagnosis and Treatment of Functional Infertility. Berlin, G Verlag, 1978, p 76

    Google Scholar 

  19. Kemmann E, Tavakoli F, Shelden RM, Jones JR: Induction of ovulation with menotropins in women with polycystic ovary syndrome. Am J Obstet Gynecol 1981;141:58–64

    PubMed  Google Scholar 

  20. Caspi E, Levin S, Bukovsky I, Weintraub Z: Induction of pregnancy with human gonadotropins after clomiphene failure in menstruating ovulatory infertility patients. Isr J Med Sci 1974;10:249–255

    Google Scholar 

  21. Haning RV, Austin CW, Carlson IH, Kuzman DL, Shapiro SS, Zweibel WJ: Plasma estradiol is superior to ultrasound and urinary estriol glucuronide as a predictor of ovarian hyperstimulation during induction of ovulation with menotropins. Fertil Steril 1983;40:31–36

    PubMed  Google Scholar 

  22. Tyler E: Treatment of anovulation with menotropins. JAMA 1968;205:86–92

    PubMed  Google Scholar 

  23. Novak J: Uber Ursache und Bedeutung des physiologischen Ascites beim Weibe. Zentralbl Gynaekol 1922;46:854–858

    Google Scholar 

  24. Bissel D: Observations on the cyclical pelvic fluid in the female. A preliminary report. Am J Obstet Gynecol 1932;24:271–273

    Google Scholar 

  25. Maathuis JB, Van Look PF, Michie EA: Changes in volume, total protein and ovarian steroid concentrations of peritoneal fluid throughout the human menstrual cycle. J Endocrinol 1978;76:123–133

    PubMed  Google Scholar 

  26. Koninckx PR, Heyns W, Verhoeven G,et al. Biochemical characterization of peritoneal fluid in women during the menstrual cycle. J Clin Endocrinol Metab 1980;51:1239–2344

    PubMed  Google Scholar 

  27. Koninckx PR, Renaer M, Brosens IA: Origin of peritoneal fluid in women. An ovarian exudation product. Br J Obstet Gynaecol 1980;87:177–183

    PubMed  Google Scholar 

  28. Donnez J, Langerock S, Thomas K: Peritoneal fluid volume and 17 b-estradiol and progesterone concentrations in ovulatory, anovulatory, and postmenopausal women. Obstet Gynecol 1982;59:687–692

    PubMed  Google Scholar 

  29. Jakob W, Jentrsch KD, Maursberger B, Oehme P: Demonstration of angiogenesis activity in the corpus luteum of cattle. Exp Pathol 1977;13:231–236

    Google Scholar 

  30. Simkins CS: Development of the human ovary from birth to sexual maturity. Am J Anat 1932;51:465–505

    Google Scholar 

  31. Cajander S, Bjersing L: Fine structural demonstration of acid phosphatase in rabbit germinal epithelium prior to induced ovulation. Cell Tissue Res 1975;164:279–289

    PubMed  Google Scholar 

  32. Novak ER, Woodruff JD: Embryology and histology of ovaries.In Novak's Gynecologic and Obstetric Pathology, 7th ed. Philadelphia, WB Saunders, 1974, pp 337–338

    Google Scholar 

  33. diZerega GS, Hodgen G: Fluorescein localization of LH/hCG uptake in the primate ovary. II. Changing distribution during selection of the dominant follicle. J Clin Endocrinol Metab 1980;51:903–907

    PubMed  Google Scholar 

  34. Zeleznik A, Schuller H, Reichert L Jr: Gonadotropin binding sites in the rhesus monkey ovary: role of the vasculature in the selective distribution of human chorionic gonadotropin to the preovulatory follicle. Endocrinology 1981;109:356–362

    PubMed  Google Scholar 

  35. Bassest D: The changes in the vascular pattern of the ovary of the albino rat during the estrous cycle. Am J Anat 1943;73:251–291

    Google Scholar 

  36. Gospodarowicz D, Thakral K: Production of a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum. Proc Natl Acad Sci USA 1978;75:847–851

    PubMed  Google Scholar 

  37. Koos R, LeMaire W: Evidence for angiogenic factor from rat follicles.In Factors Regulating Ovarian Function, GS Greenwald, PF Terranova (eds). New York, Raven Press, 1983, pp 191–195

    Google Scholar 

  38. Sato E, Ishibashi T, Koide SS: Inducement of blood vessel formation by ovarian extracts from mice injected with gonadotropins. Experientia 1982;38:1248–1249

    PubMed  Google Scholar 

  39. Curry TE, Koos RD: Ovarian transplants are capable of stimulating new blood vessel growth. Biol Reprod (Suppl) 1984;303:37–40

    Google Scholar 

  40. Frederick JL, Shimanuki T, diZerega GS: Initiation of angiogenesis by human follicular fluid. Science 1984;224:389–390

    PubMed  Google Scholar 

  41. Makris A, Ryan KJ, Yasumizu T, Hill CL, Zetter BR: The nonluteal porcine ovary as a source of angiogenic activity. Endocrinology 1984;115:1672–1677

    PubMed  Google Scholar 

  42. Frederick JL, Hoa N, Preston DS, Frederick JJ, Campeau JD, Onto T, diZerega GS: Initiation of angiogenesis by porcine follicular fluid. Am J Obstet Gynecol 1985;152:1073–1078

    PubMed  Google Scholar 

  43. Fernandez LA, Tazlatzis BC, Rzasa PJ, Caride VJ, Laufer N, Negro-Vilar AF, DeCherney AH, Naftolin F: Renin-like activity in ovarian follicular fluid. Fertil Steril 1985;44:219–223

    PubMed  Google Scholar 

  44. Alexander RW, Gimbrone MA, JR: Prostaglandin production by vascular smooth muscle in tissue culture. Proc Natl Acad Sci USA 1976;71:1617–1620

    Google Scholar 

  45. Paulson RJ, Hernandez MF, Do YS, Hsuesh WA: Angiotensin II modulation of steroidogenesis by luteinizing granulosa cells in vitro. Society for Gynecologic Investigation, San Diego, CA, March 15–18, 1900, Abstr 197

    Google Scholar 

  46. Fernandez LA, Twickler J, Mead A: Neovascularization produced by angiotensin II. J Lab Clin Med 1985;105:141–145

    PubMed  Google Scholar 

  47. Sealey JE, Atlas SA, Laragh JH: Prorenin and large molecular weight forms of renin. Endocr Rev 1980;1:365–391

    PubMed  Google Scholar 

  48. Bouhnik J, Fehrentz JA, Galen FX, Seyer R, Evin G, Castro B, Menard J, Corvol P: Immunologic identification of both plasma and human renal inactive renin as prorenin. J Clin Endocrinol Metab 1985;60:399–401

    PubMed  Google Scholar 

  49. Atlas SA, Christofalo P, Hesson T, Sealey JE, Fritz L: Immunological evidence that inactive renin is prorenin. Biochem Biophys Res Commun 1985;132:1038–1045

    PubMed  Google Scholar 

  50. Weinberger MH, Wades MB, Aoi W, Usa T, Detino M, Luft F, Grim CE: An extrarenal source of “renin-like” activity in anephric man. Circ Res (Suppl 1) 1977;40:1–5

    Google Scholar 

  51. Sealey JE, White RP, Laragh JH, Rubin AL: Plasma prorenin and renin in anephric patients. Circ Res (Suppl 2) 1977;41:17–20

    Google Scholar 

  52. Symonds EM, Stanley MA, Skinner SL: Production of renin by in vitro cultures of human chorion and uterine muscle. Nature 1968;217:1152–1153

    PubMed  Google Scholar 

  53. Sealey JE, Cholst I, Glorioso N, Troffa C, Weintraub ID, James G, Laragh J: Sequential changes in plasma luteinizing hormone and plasma prorenin during the menstrual cycle. J Clin Endocrinol Metab 1987;63:1–5

    Google Scholar 

  54. Reid IA, Morris BJ, Ganong WF: The renin angiotensin system. Annu Rev Physiol 1978;40:377–410

    PubMed  Google Scholar 

  55. Skeggs LT, Dorer FE, Kahn JR, Lentz KE, Levine M: The biochemistry of the renin-angiotensin system and its role in hypertension. Am J Med 1976;60:737–748

    PubMed  Google Scholar 

  56. Sealey JE, Atlas SA, Gloriosi N, Manapat H, Laragh JH: Cyclical secretion of prorenin during the menstrual cycle: Synchronization with luteinizing hormone and progesterone. Proc Natl Acad Sci USA 1985;82:8705–8709

    PubMed  Google Scholar 

  57. Sealey JE, Cholst I, Glorioso N, Troffa C, Weintraub ID, James G, Laragh J: Sequential changes in plasma luteinizing hormone and plasma prorenin during the menstrual cycle. J Clin Endocrinol Metab 1987;63:1–5

    Google Scholar 

  58. Cholst I, Troffa C, Weintraub I, Sealey JE: Plasma prorenin, LH, and estradiol relationships during the early luteal phase of the menstrual cycle. 68th Annual Meeting of the Endocrine Society, Anaheim, CA, 1986, p 74 (abstr 173)

  59. Chesley LC, Tepper IH: Effects of progesterone and estrogen on the sensitivity to angiotensin II. J Clin Endocrinol Metab 1967;27:576–581

    PubMed  Google Scholar 

  60. Oparil S, Ehrlich EN, Lindheimer MD: Effect of progesterone on renal sodium handling in man: Relation to aldosterone excretion and plasma renin activity. Clin Sci Mol Med 1975;49:139–147

    PubMed  Google Scholar 

  61. Brown JJ, Davies DL, Lever AF, Robertson JIS: Variations in plasma renin during the menstrual cycle. Br Med J 1964;2:1114–1115

    Google Scholar 

  62. Skinner SL, Lumbers ER, Symonds EM: Alteration by oral contraceptives of normal menstrual changes in plasma renin activity, concentration and substrate. Clin Sci 1969;36:67–76

    PubMed  Google Scholar 

  63. Katz FH, Romfh P: Plasma aldosterone and renin activity during the menstrual cycle. J Clin Endocrinol Metab 1972;34:819–821

    PubMed  Google Scholar 

  64. Atlas SA, Sealey JE, Laragh JH, Moon C: Plasma renin and “prorenin” in essential hypertension during sodium depletion, beta-blockade, and reduced arterial pressure. Lancet 1977;2:785–789

    PubMed  Google Scholar 

  65. Weinberger M, Ao W, Grim C: Dynamic response of active and inactive renin in normal and hypertensive humans. Circ Res 1977;41(Suppl 2):21–26

    PubMed  Google Scholar 

  66. Sealey JE, Glorioso N, Toth A, Atlas SA, Laragh JH: Stimulation of plasma prorenin by gonadotropic hormones. Am J Obstet Gynecol 1985;153:596 (letter)

    PubMed  Google Scholar 

  67. Istovitz J, Glorioso N, Sealey JE, Rosenwacks A: Prorenin response to hCG is directly related to the number of ovarian follicles. 18th Annual Meeting of the American Fertility Society/Canadian Fertility and Andrology Society, Toronto, Canada, 1986, p 10 (abstr)

  68. Sealey JE, Glorioso N, Istovitz J, Troffa C, Cholst I, Rosenwaks A: Plasma prorenin during early pregnancy: Ovarian secretion under gonadotropin control? J Hypertens (Suppl 5) 1986;4:S92-S95

    Google Scholar 

  69. Sealey JE, McCord D, Taufield PA, Ales KA, Druzin ML, Atlas SSA, Laragh JH: Plasma prorenin in first trimester pregnancy: Relationship to changes in human chorionic gonadotropin. Am J Obstet Gynecol 1985;153:514–519

    PubMed  Google Scholar 

  70. Glorioso N, Atlas SA, Laragh JH, Jewelewicz R, Sealey JE: Prorenin in high concentrations in human follicular fluid. Science 1986;233:1422–1424

    PubMed  Google Scholar 

  71. Navot D, Margalioth EJ, Laufer N, Birkenfeld A, Relou A, Rosler A, Schenker JG: Direct correlation between plasma renin activity and severity of the ovarian hyperstimulation syndrome. Fertil Steril 1987;48:57–61

    PubMed  Google Scholar 

  72. Ong ACM, Eisen V, Rennie DP, Homburg R, Lavchelin GCL, Jacobs HS, Slater JDH: The pathogenesis of the ovarian hyperstimulation syndrome (OHS): a possible role for ovarian renin. Clin Endocrinol 1991;34:43–49

    Google Scholar 

  73. Hanining RV, Strawn EY, Nolten WE: Pathophysiology of the ovarian hyperstimulation syndrome. Obstet Gynecol 1985;66:220–224

    PubMed  Google Scholar 

  74. Engel T, Jewelewicz R, Dyrenfurth I, Speroff L, Van de Wiele RL: Ovarian hyperstimulation syndrome. Report of a case with notes on pathogenesis and treatment. Am J Obstet Gynecol 1972;112:1052–1060

    PubMed  Google Scholar 

  75. Jewelewicz R, Dyrenfurth I, Warren MP, Van de Wiele RL: Ovarian hyperstimulation syndrome-relationship between preovulatory estrogen levels and ovarian hyperstimulation in gonadotropin-treated patients.In Gonadotropin Therapy in Female Fertility, E Rosemberg (ed). Amsterdam, Excerpta Medica No. 266, 1900, pp 235–245

  76. Jarhault J: Comparative effects of angiotensin and norepinephrine on resistance, capacitance and precapillary sphincter vessels on cat skeletal muscle. Acta Physiol Scand 1971;81:315–324

    PubMed  Google Scholar 

  77. Robertson AL, Khairallah PA: Effects of angiotensin II and some analogues on vascular permeability in the rabbit. Circ Res 1972;31:923–931

    PubMed  Google Scholar 

  78. Cuttino JT, Bartrum RJ, Hollenberg NK, Abrams HL: Collateral vessel formation: Isolation of a transferable factor promoting a vascular response. Basic Res Cardiol 1975;70:568–573

    PubMed  Google Scholar 

  79. Ilich N, Hollenberg NK, Connely CM, Williams DH, Abrams HL: Increased collateral arterial and venous endothelial cell turnover after renal artery stenosis in the dog. Invest Radiol 1978;13:143–149

    PubMed  Google Scholar 

  80. Schenker JG, Polishuk WZ: The role of prostaglandins in ovarian hyperstimulation syndrome. Eur J Obstet Gynecol Reprod Biol 1976;6:47–50

    PubMed  Google Scholar 

  81. Katz Z, Lancet M, Borenstein R, Chenke J: Absence of teratogenicity of indomethacin in ovarian hyperstimulation syndrome. Int J Fertil 1984;29:186–188

    PubMed  Google Scholar 

  82. Pride SM, Yuen BH, Moon YS, Leyung PCS: Relationship of gonadotropin-releasing hormone, danazol and prostaglandin blockade to ovarian enlargement and ascites formation of the ovarian hyperstimulation syndrome in the rabbit. Am J Obstet Gynecol 1986;154:1155–1160

    PubMed  Google Scholar 

  83. Borenstein R, Elhalah U, Lunenfeld B, Shoham-Schwartz Z: Sever ovarian hyperstimulation syndrome: A reevaluated therapeutic approach. Fertil Steril 1989;51:791–795

    PubMed  Google Scholar 

  84. Gergely RZ, Paldi E, Erlik Y, Makler A: Treatment of ovarian hyperstimulation syndrome by antihistamine. Obstet Gynecol 1976;47:83–85

    PubMed  Google Scholar 

  85. Knox GE: Antihistamine blockade of the ovarian hyperstimulation syndrome. Am J Obstet Gynecol 1974;118:992–994

    PubMed  Google Scholar 

  86. Pride SM, Yeun BH, Moon YS: Clinical, endocrinologic, and intraovarian prostaglandin F response to H-1 receptor blockade in the ovarian hyperstimulation syndrome: Studies in the rabbit model. Am J Obstet Gynecol 1984;148:670–674

    PubMed  Google Scholar 

  87. Erlik Y, Naot Y, Friedman M, Ben-David E, Paldi E: Histamine levels in ovarian hyperstimulation syndrome. Obstet Gynecol 1979;53:580–582

    PubMed  Google Scholar 

  88. Zaides I, Friedman M, Lindenbaum ES,et al. Serotonin and the ovarian hyperstimulation syndrome. Eur J Obstet Gynecol Reprod Biol 1983;15:55–61

    PubMed  Google Scholar 

  89. Dinarello CA: Interleukin-1 and its related cytokines. Adv Immunol 1989;44:153–205

    PubMed  Google Scholar 

  90. Hume DA, Halpin D, Charlton H, Gordon S: The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of endocrine organs. Proc Natl Acad Sci USA 1984;81:4174–4177

    PubMed  Google Scholar 

  91. Nakamura Y, Smith M, Krishna A, Terranova PF: Increased number of mast cells in the dominant follicle of the cow; Relationships among luteal, stromal, and hilar regions. Biol Reprod 1987;37:546–549

    PubMed  Google Scholar 

  92. Loukides JA, Loy RA, Edwards R, Honig J, Visintin I, Polan ML: Human follicular fluids contain tissue macrophages. J Clin Endocrinol Metab 1990;71:1363–1367

    PubMed  Google Scholar 

  93. Seow WK, Thong YH, Waters M, Walters M, Cummins JM: Isolation of a chemotactic protein for neutrophils from human ovarian follicular fluid. Int Arch Allergy Appl Immunol 1988;86:331–336

    PubMed  Google Scholar 

  94. Zolti M, Ben-Rafael Z, Meirom R, Shemesh M, Bider D, Mashiach S, Apte RN: Cytokine involvement in oocyte and early embryos. Fertil Steril 1991;56:265–272

    PubMed  Google Scholar 

  95. Gray PW, Glaister D, Chen E, Goeddel DV, Pennica D: Two interleukin 1 genes in the mouse: Cloning and expression of the cDNA for murine interleukin 1 beta. J Immunol 1986;137:3644–3648

    PubMed  Google Scholar 

  96. March CJ, Mosley B, Larsen A, Ceretti DP, Braedt G, Price V, Gillis S, Henney CS, Kronheim SR, Grabstein K, Conlon PJ, Hopp TP, Cosman D: Cloning, sequence and expression of two distinct human interleukin-1 complementary DNA's. Nature 1985;315:641–647

    PubMed  Google Scholar 

  97. Fukuoka M, Mori T, Taii S, Yasuda K: Interleukin-1 inhibits luteinization of porcine granulosa cells in culture. Endocrinology 1987;122:367–369

    Google Scholar 

  98. Fukuoka M, Yasuda K, Taii S, Takakura K, Mori T: Interleukin-1 stimulates growth and inhibits progesterone secretion in the cultures of porcine granulosa cells. Endocrinology 1989;124:884–890

    PubMed  Google Scholar 

  99. Gottschall PE, Uehara A, Hoffmann ST, Arimura A: Interleukin-1 inhibits follicle stimulating hormone-induced differentiation in rat granulosa cells in vitro. Biochem Biophys Res Commun 1987;149:502–509

    PubMed  Google Scholar 

  100. Gottschall PE, Katsuura G, Dahl RR, Hoffmann ST, Arimura A: Discordance in the effects of interleukin-1 on rat granulosa cell differentiation induced by folliclestimulating hormone or activators of adenylate cyclase. Biol Reprod 1988;39:1074–1085

    PubMed  Google Scholar 

  101. Gottschall PE, Katsuura G, Hoffmann ST, Arimura A: Interleukin-1: an inhibitor of luteinizing hormone receptor formation in cultured rat granulosa cells. FASEB J 1988;2:2492

    PubMed  Google Scholar 

  102. Gottschall PE, Katsuura G, Arimura A: Interleukin-1 beta is more potent than interleukin-1 alpha in suppressing follicle-stimulating hormone-induced differentiation of ovarian granulosa cells. Biochem Biophys Res Commun 1989;163:764–777

    PubMed  Google Scholar 

  103. Mori T, Masatsune F, Yasuda K, Takakura K, Toshiko I, Tai S: Modulation of porcine granulosa cell functions by interleukin-1. Steroids 1989;54:543–552

    PubMed  Google Scholar 

  104. Nakamura Y, Kato H, Terranova PF: Interleukin-lα increases thecal progesterone production of preovulatory follicles in cyclic hamsters. Biol Reprod 1990;43:169–173

    PubMed  Google Scholar 

  105. Nothnick WB, Pate JL: Interleukin-1β is a potent stimulator of prostaglandin synthesis in bovine luteal cells. Biol Reprod 1990;43:898–903

    PubMed  Google Scholar 

  106. Hurwitz A, Ricciarelli E, Katz E, Botero L, McAllister JM, Loukides J, Adashi EY, Hernandez ER: Expression of interleukin-1, its receptor, and its receptor antagonist genes in the human ovary. 38th Annual Meeting of SGI, 1991, abstr 5

  107. Cannon JG, Dinarelli, CA: Increased plasma interleukin-1 activity in women after ovulation. Science 1985;227:1247–1249

    PubMed  Google Scholar 

  108. Motro B, Itin A, Sachs L, Keshet E: Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis. Cell Biol 1990;87:3092–3096

    Google Scholar 

  109. Ryley NG, Forman R, Barlow D, Fleming KA, Trowell JM: Liver abnormality in ovarian hyperstimulation syndrome. Hum Reprod 1990;5:938–943

    PubMed  Google Scholar 

  110. Kaaja R, Sieberg R, Tiitinen A, Koskimies A: Severe ovarian hyperstimulation syndrome and deep venous thrombosis. Lancet 1989;2:1043 (letter)

    Google Scholar 

  111. Bazett HC, Sunderman FW, Doupe J, Scott JC: Climatic effects on the volume and composition of blood in man. Am J Physiol 1940;129:69–83

    Google Scholar 

  112. Stein HJ, Eliot JW, Bader RA: Physiological reactions to col and their effects on the retention of acclimatization to heat. J Appl Physiol 1948;1:575–585

    Google Scholar 

  113. Guyton AC: Textbook of Medical Physiology. Philadelphia, WB Saunders, 1991, pp 156–157

    Google Scholar 

  114. Gregerson MI: Blood volume. Physiol Rev 1959;39:307–342

    PubMed  Google Scholar 

  115. Bullard RW, Dill DB, Yousef MK: Responses of the burro to desert heat stress. J Appl Physiol 1970;29:159–167

    PubMed  Google Scholar 

  116. Joye H, Portmans JR: Hematocrit and serum proteins during arm exercise. Med Sci Sports 1970;2:187–190

    PubMed  Google Scholar 

  117. Poortmans JR: Influence of physical exercise on proteins in biological fluids.In Biochemistry of Exercise, Proceedings of the First Symposium of Exercise, Poortmans J (ed). 1968, pp 312–327

  118. Poortmans JR: Serum protein determination during short exhaustive physical activity. J Appl Physiol 1970;30:190–192

    Google Scholar 

  119. Saltin B: Circulatory response to submaximal and maximal exercise after thermal dehydration. J Appl Physiol 1964;19:1125–1132

    PubMed  Google Scholar 

  120. Senay LC Jr, Christensen ML: Changes in blood plasma during progressive dehydration. J Appl Physiol 1965;20:1136–1140

    Google Scholar 

  121. Senay LC Jr: Movement of water, protein and crystalloid between vascular and extra vascular compartments in heatexposed men during dehydration and following limited relief of dehydration. J Physiol London 1970;210:617–635

    PubMed  Google Scholar 

  122. van Beaumont W: Evaluation of hemoconcentration from hematocrit measurements. J Appl Physiol 1972;5:712–713

    Google Scholar 

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  1. Department of Obstetrics Gynecology and Reproductive Science, Mount Sinai Medical Center, 10029, New York, New York, USA

    Paul A. Bergh & Daniel Navot

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Bergh, P.A., Navot, D. Ovarian hyperstimulation syndrome: A review of pathophysiology. J Assist Reprod Genet 9, 429–438 (1992). https://doi.org/10.1007/BF01204048

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