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Epidemiology of dust-mite-related disease

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Abstract

For many years it has been suggested that allergens derived from the house dust mite played a major role in the pathogenesis of asthma, eczema and some cases of allergic rhinitis. Recently, house dust mite allergens have been purified and specific immunoassays developed with which exposure to house dust mites and their allergens can be more easily determined. Using these tools, epidemiological studies have provided confirmatory evidence that not only is house dust mite exposure associated with the majority of cases of asthma in children and young adults, but that it is causally related to the development of asthma.

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References

  • Barnetson, R.S.C., MacFarlane, H.A.F. and Benton, E.C., 1987. House dust mite allergy and atopic eczema. Br. J. Dermatol., 116: 857–860.

    PubMed  Google Scholar 

  • Bousquet, J., Chanez, P., Lacoste, J.Y., Barndeon, G., Ghavania, N., Enander, I., Venge, P., Ahlstedt, S., Simony-Lafontaine, J. and Godard, P., 1990. Eosinophilic inflammation in asthma. N. Engl. J. Med., 323: 1033–1039.

    PubMed  Google Scholar 

  • Chapman, M.D., Rowntree, S., Mitchell, E.B., Di Prisco Fuenmajor, M.C. and Platts-Mills, T.A.E., 1983. Quantitative assessment of IgG and IgE antibodies to inhalant allergens in patients with atopic dermatitis. J. Allergy Clin. Immunol., 72: 27–33.

    PubMed  Google Scholar 

  • Chapman, M.D., Heymann, P.W., Wilkins, S.R., Brown, M.B. and Platts-Mills, T.A.E., 1987. Monoclonal immunoassays for the major dust mite (Dermatophagoides) allergen,Der p I andDer fI and quantitative analysis of the allergen content of mite and house dust extracts. J. Allergy Clin. Immunol., 80: 184–194.

    PubMed  Google Scholar 

  • Charpin, D., Birnbaum, J., Haddie, E., Genard, G., Toumi, M. and Vervolet, D., 1990. Attitude and allergy to house dust mites: an epidemiological study in primary school children. J. Allergy Clin. Immunol., 85: 185 (abstract).

    Google Scholar 

  • Clark, P.S., 1987. The diagnosis of perennial rhinitis due to house dust mite (Dermatophagoides pteronyssinus) demonstrated by nasal provocation tests. Ann. Allergy, 59: 25–28.

    Google Scholar 

  • Deuell, B., Wilson, B., Heymann, P. and Platts-Mills, T., 1991. Atopic dermatitis: The role of dust mite allergy and monitoring of disease activity by assay of IgG in skin scales. J. Allergy Clin. Immunol., 87: 237 (abstract).

    Google Scholar 

  • Devlin, J., David, T.J. and Stanton, R.H.J., 1991. Elemental diet for refractory atopic eczema. Arch. Dis. Child., 66: 93–99.

    PubMed  Google Scholar 

  • Dilworth, R.J., Chua, K.Y. and Thomas, W.R., 1991. Sequence analysis of cDNA coding for a major house dust mite allergen,Der fI. Clin. Exp. Allergy, 21: 25–32.

    PubMed  Google Scholar 

  • Di Nicolo, R., Nelson, R.P., Fernandez-Caldas, E., Trudeau, W., Swanson, M., Bonini, L.V., Perez, A., Arthur, P., Lockey, R. and Good, R.A. 1991. Allergen-specific IgE levels in children presenting to the emergency room with acute asthma. J. Allergy Clin. Immunol., 87: 234 (abstract).

    Google Scholar 

  • Djukanovic, R., Roche, W.R., Wilson, J.W., Beasley, C.R.W., Twentyman, O.P., Howarth, P.H. and Holgate, S.T., 1990. Mucosal inflammation in asthma. Am. Rev. Respir. Dis., 142: 434–457.

    PubMed  Google Scholar 

  • Dowse, G.K., Smith, D., Turner, K.J. and Alpers, M.P., 1985. Prevalence and features of asthma in a sample survey of urban Goroka, Papua New Guinea. Clin. Allergy, 15: 429–438.

    PubMed  Google Scholar 

  • Ehnert, B., Lau-Schadendorf, S., Weber, A., Buettner, P., Schou, C. and Wahn, U., 1992. Reducing domestic exposure to dust mite allergen reduces bronchial hyperreactivity in sensitive children with asthma. J. Allergy Clin. Immunol., 90: 135–138.

    PubMed  Google Scholar 

  • Herxheimer, H. and Schaefer, O., 1975. Asthma in Canadian Eskimos. N. Engl. J. Med., 291: 1419 (letter).

    Google Scholar 

  • Hill, A.B., 1965. The environment and disease: Association or causation? Proc. R. Soc. Med., 58: 295–300.

    PubMed  Google Scholar 

  • Hosen, H., 1988. The diagnosis of perennial rhinitis due to the house dust mite demonstrated by nasal provocative tests. Ann. Allergy, 60: 462 (letter).

    PubMed  Google Scholar 

  • Kern, R.A., 1921. Dust sensitization in bronchial asthma. Med. Clin. North Am., 5: 751–758.

    Google Scholar 

  • Lau, S., Falkenhorst, G., Weber, A., Werthmann, I., Lind, P., Buettner-Goetz, P. and Wahn, U., 1989. High mite-allergen exposure increases the risk of sensitisation in atopic children and young adults. J. Allergy Clin. Immunol., 84: 718–725.

    PubMed  Google Scholar 

  • Lobitz, W.C. and Jillson, O.F., 1958. Anecdotes of an agnostic allergist. Arch. Dermatol., 78: 458.

    Google Scholar 

  • Marsh, D.G., 1975. Allergens and the genetics of allergy. In: M. Sela (Editor), The Antigens, Vol. 3. Academic Press, New York, NY, pp. 271–295.

    Google Scholar 

  • Mitchell, E.B., Crow, J., Chapman, M.D., Jouhal S.S., Pope, F.M. and Platts-Mills, T.A.E., 1982. Basophils in allergen induced path test sites in atopic dermatitis. Lancet, 1: 127–130.

    PubMed  Google Scholar 

  • Miyamoto, T., Oshima, S., Ishizaki, T. and Sato, S., 1968. Allergenic identity between the common floor mite (Dermatophagoides farinae Hughes 1961) and house dust as a causative agent in bronchial asthma. J. Allergy, 42: 14–28.

    PubMed  Google Scholar 

  • O'Hallaran, M.T., Yunginger, J.W., Offord, K.P., Somers, M.J., O'Connel, E.J., Ballard, D.J. and Sachs, M.I., 1991. Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N. Engl. J. Med., 324: 359–363.

    PubMed  Google Scholar 

  • Ohman, S. and Johansson, S.G., 1974. Allergen specific IgE in atopic dermatitis. Acta Dermatol. Venerol., 54: 283–290.

    Google Scholar 

  • Ohman, J.L., Nadakavukaren, J.J., Sparrow, D. and MacDonald, M.R., 1991. Mite sensitization and current smoking are related to new onset asthma in older males. J. Allergy Clin. Immunol., 87: 719 (abstract).

    Google Scholar 

  • Perason, R.S.B., 1973. Asthma in Barbados, Clin. Allergy 3: 289–297.

    PubMed  Google Scholar 

  • Peat, J.K., Britton, W.J., Salome, C.M. and Woolcock, A.J., 1987. Bronchial hyperresponsiveness in two populations of australian schoolchildren. III Effect of exposure to environmental allergens. Clin. Allergy, 17: 297–300.

    Google Scholar 

  • Platts-Mills, T.A.E. and De Weck, A.L., 1989. Report of an international workshop. Dust mite allergens and asthma: a worldwide problem. J. Allergy Clin. Immunol., 83: 416–427.

    PubMed  Google Scholar 

  • Platts-Mills, T.A.E., Tovey, E.R., Mitchell, E.B., Moszoro, H., Nock, P. and Wilkins, S.R., 1982. Reduction of bronchial hyperreactivity during prolonged allergen avoidance. Lancet, 2: 675–678.

    PubMed  Google Scholar 

  • Platts-Mills, T.A.E., Hayden, M.L., Chapman, M.D. and Wilkins, S.R., 1987. Seasonal variation in dust mite and grass pollen allergen in dust from the houses of patients with asthma. J. Allergy Clin. Immunol., 79: 781–791.

    PubMed  Google Scholar 

  • Platts-Mills, T.A.E., Chapman, M.D., Pollart, S.M., Heymann, P.W. and Luczynska, C.M., 1990. Establishing health standards for indoor foreign proteins related to asthma: Dust mite, cat, cockroach. Toxicol. Ind. Health, 6: 197–208.

    PubMed  Google Scholar 

  • Pollart, S.M., Reid, M.J., Fling, J.A., Chapman, M.D. and Platts-Mills, T.A., 1988. Epidemiology of emergency room asthma in northern California: association with IgE antibody to rye grass pollen. J. Allergy Clin. Immunol., 82: 224–230.

    PubMed  Google Scholar 

  • Price, J.A., Pollock, J., Little, S.A., Longbottom, J.L. and Warner, J.O., 1990. Measurements of airborne mite allergen in homes of asthmatic children. Lancet, 336: 895–897.

    PubMed  Google Scholar 

  • Rawle, F.R., Mitchell, E.B. and Platts-Mills, T.A.E., 1984. T cell responses to the major allergen from the house dust miteDermatophagoides pteronyssinus, antigen P1: comparison of patients with asthma, atopic dermatitis, and perennial rhinitis. J. Immunol., 133: 195–201.

    PubMed  Google Scholar 

  • Roberts, D., 1984. House dust avoidance and atopic dermatitis. Br. J. Dermatol., 110: 735–736.

    PubMed  Google Scholar 

  • Rothman, K.J., 1986. Causal inference in epidemiology. In: Modern Epidemiology. Little, Brown and Company, Boston/Toronto, pp. 7–21.

    Google Scholar 

  • Sarsfield, J.K., 1974. Role of house-dust mites in childhood asthma. Arch. Dis. Child., 49: 711–716.

    PubMed  Google Scholar 

  • Smith, J.M. and Springett, V.H., 1979. Atopic disease and month of birth. Clin. Allergy, 9: 153–157.

    PubMed  Google Scholar 

  • Smith, J.M., Disney, M.E., Williams, J.D. and Goels, Z.A., 1969. Clinical significance of skin reactions to mite extracts in children with asthma. Br. Med. J., 1: 723–726.

    PubMed  Google Scholar 

  • Sporik, R., Holgate, S.T., Platts-Mills, T.A.E. and Cogswell, J.J., 1990. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood. A prospective study. N. Engl. J. Med., 323: 502–507.

    PubMed  Google Scholar 

  • Sporik, R., Platts-Mills, T.A.E. and Cogswell, J.J., 1991. Exposure and sensitisation of children admitted to hospital with asthma to house dust mite allergen (Der p I). J. Allergy Clin. Immunol., 87: 291 (abstract.).

    Google Scholar 

  • Tovey, E.R., Chapman, M.D., Wells, C.W. and Platts-Mills, T.A., 1981. The distribution of dust mite allergen in the houses of patients with asthma. Am. Rev. Respir. Dis., 124: 630–635.

    PubMed  Google Scholar 

  • Trudinger, M., Chua, K.Y. and Thomas, W.R., 1991. cDNA coding the major mite allergenDer fII. Clin. Exp. Allergy, 21: 33–37.

    PubMed  Google Scholar 

  • Tuft, L.A., 1949. Importance of inhalant allergens in atopic dermatitis. J. Invest. Dermatol., 12: 211–219.

    Google Scholar 

  • van der Brempt, X., Haddi, E., Michel-Nguyen, A., Fayon, J.P., Soler, M., Charpin, D. and Vervloet, D., 1991. Comparison of the ACAREX test with monoclonal antibodies for quantification of mite allergens. J. Allergy Clin. Immunol., 87: 130–132.

    PubMed  Google Scholar 

  • van Leeuwen, W.S., 1927. Asthma and tuberculosis in relation to climate allergens. Br. Med. J., 2: 344–347.

    Google Scholar 

  • Voorhorst, T., Spieksma, F.Th.M., Varekamp, H., Leupen, M.J. and Lyklema, A.W., 1967. The house dust mite (Dermatophagoides pteronyssinus) and the allergens it produces: identity with the house dust allergen. J. Allergy, 39: 325–339.

    Google Scholar 

  • Warner, J.O., 1976. Significance of late reactions after bronchial challenge with house dust mite. Arch. Dis. Child., 51: 905–911.

    PubMed  Google Scholar 

  • Zeiger, R.S., 1988. The development and prevention of allergic disease in childhood. In: E. Middleton, C.E. Reed, E.F. Ellis, N.F. Adkinson and J.W. Yunginger (Editors), Allergy: Principles and Practice, 3rd edition. Mosby, pp. 930–968.

  • Zimmerman, T., 1987. Reduzierung der Hausstaubmilben Allergene nach Zimmer und Bettsäuberung. Untersuchung mit echem Teglstreifer System (Acarex). Allergologie, 10: 3.

    Google Scholar 

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  1. Division of Allergy and Clinical Immunology, University of Virginia, 22908, Charlottesville, VA, USA

    Richard Sporik & Thomas A. E. Platts-Mills

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  1. Richard Sporik
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  2. Thomas A. E. Platts-Mills
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Sporik, R., Platts-Mills, T.A.E. Epidemiology of dust-mite-related disease. Exp Appl Acarol 16, 141–151 (1992). https://doi.org/10.1007/BF01201497

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