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A review of recent immunochemical studies ofBlomia tropicalis andEuroglyphus maynei allergens

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Abstract

Exposure to mites other thanDermatophagoides spp., particularlyBlomia tropicalis andEuroglyphus maynei, has been increasingly recognized as a cause of asthma. Positive skin tests and serum IgE antibodies toB. tropicalis have been reported in asthmatic patients from several areas of the world, including São Paulo (Brazil), Hong Kong and Tampa (Florida, USA). Analysis ofB. tropicalis extracts showed undetectable levels of the major Group I and Group IIDermatophagoides spp. allergens. Immunoabsorption experiments showed that most of the IgE antibodies toB. tropicalis (∼ 70%) reacted with species-specific allergens. Murine monoclonal antibodies toB. tropicalis could present antigens that were recognized by human IgG antibodies. Sensitization toE. maynei has been reported in Europe, North and South America and Australia. Analysis of four differentE. maynei extracts by ELISA and RIA showed thatE. maynei produces an allergen that is antigenically related toDermatophagoides Group I allergens. The amino acid sequence of this allergen (Eur m I) has recently been reported. Further identification and purification ofB. tropicalis andE. maynei allergens is required to develop specific assays for measuring these allergens in dust samples. This will make it possible to investigate the relationship between exposure toB. tropicalis orE. maynei and the development of sensitization and allergic disease.

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Authors and Affiliations

  1. Division of Allergy and Clinical Immunology, Department of Medicine, University of Virginia, Box 225, 22908, Charlottesville, VA, USA

    L. Karla Arruda & Martin D. Chapman

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  1. L. Karla Arruda
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  2. Martin D. Chapman
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Arruda, L.K., Chapman, M.D. A review of recent immunochemical studies ofBlomia tropicalis andEuroglyphus maynei allergens. Exp Appl Acarol 16, 129–140 (1992). https://doi.org/10.1007/BF01201496

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