Summary
Several well tolerated materials are currently available for the treatment of hernias. Polyester (Dacron) and polypropylene (PPL) are currently the most frequently used materials. Experimental work has highlighted the biological response of laboratory animals treated with a range of prostheses. Authors agree that an inflammatory response rarely occurs, although materials generate a range of responses. In the years 1996–2000, hystological tests were performed to assess thein vivo response to the range of materials. Thirty-five prostheses were examined in 34 patients. Twenty-six were men and 8 were women with an average age of 59.3 years (range 35 to 89). Samples were fixed in formalin, de-hydrated and placed in paraffin. Four micron sections were dyed with hematoxylin and eosin and then underwent microscopy. The type and the amount of prosthesis-englobin connective tissue was evaluated, as was the number of giant cells, of inflammatory elements and of vessels. Evaluation scores ranged from-to ++. The microscope highlighted a range of patterns according to the implant: a) Dacron prostheses were surrounded by a large amount of thick connective tissue, with scarce fibroblastic elements, engendering a lively response with polynucleate giant cells in relatively large quantities, b) PPL plug prostheses were englobed in a looser connective tissue, rich in fibroblasts and with a scarce amount of inflammatory elements and giant cells, c) PPL patches were surrounded by thicker connective tissue, appear to be more inert, and were often surrounded by adipose tissue. The type of prostheses, as well as its form, may engender different tissue responses.
Similar content being viewed by others
References
Arnaud JP, Eloy R, Adloff M, Grenier JF (1977) Critical evaluation of prosthetic materials in repair of abdominal wall hernias. Ara J Surg 133: 338–45
Bellon JM, Contreras La, Bujan J, Palomares D, Carrera-San Martin A (1998) Tissue response to polypropylene meshes used in the repair of abdominal wall defects. Biomaterials 19: 669–675
Coda A, Botto-Micca F, Bossotti M, Manfredi S, Mattio M, Ramellini G, Canavesio N, Bona A (1998) Re-operations for chronic infections following prosthetic hernia repair. Hernia 2: 163–167
Coda A, Ferri F, Filippa C, Mattio R, Bona A, Ramellini G (1999) Open mesh-plug repair for primary inguinal hernia (826 cases). Hernia 3: 57–63
Coda A, Benedetto C, Mattio R, Filippa C, Ferri F, Bona A (1996) Trelex Natural mesh: technical data and personal experience. Int J Surg Sci 3, [Suppl 1]: 94–97
Dabrowiecki S, Svanes K, Levken J, Grong K (1991) Tissue reaction to polypropylene mesh: a study of oedema, blood flow and inflammation in the abdominal wall. Eur Surg Res 23: 240–9
Dasdia T, Bazzacco S, Bottero L, Buffa R, Ferrero S, Campanelli G, Dolfini E (1998) Organ culture in 3-dimensional matrix: in vitro model for evaluating biological compliance of synthetic meshes for abdominal wall repair. J Biomed Mat Res 43: 204–9
Dieudonné G (1992) L'oblitération de trajets herniaires par bouchon de tulle prothétique. Chirurgie 118: 377–381
Klosterhalfen B, Klinge U, Schumpelick V (1998) Functional and morphological evaluation of different polypropylene mesh modification for abdominal wall repair. Biomaterials 19: 2235–2246
Klosterhalfen B, Klinge U, Hermanns B, Schumpelick V (2000) Pathology of traditional surgical nets for hernia repair after long-term implantation in humans. Chirurg 71: 43–51
Klosterhalfen B, Klinge U (1999) Biocompatibility of Biomaterials — Histological aspects, In: Shumpelick V, Kingsnorth AN (eds) Incisional hernia, Springer-Verlag, Berlin, pp 198–216
Petit J, Stoppa R, Baillet J (1974) Evaluation expérimentale des réactions tissulaires autour des prothèses de la paroi abdominale en tulle de dacron en fonction de la durée d'implantation et du siège en profondeur. J Chir 107: 667–672
Rath AM, Zhang J, Amouroux J, Chevrel JP (1996) Les prothèses pariétales abdominales. Etude biomécanique et histologique. Chirurgie 121: 253–65
Stoppa RE, Rives J, Warlaumont CR, et al. (1984) The use of dacron in the repair of hernias of the groin. Surg Clin N Amer 64: 269–74
Trabucchi E, Corsi FR, Meinardi C, Cellerino P, Allevi R, Foschi DA (1998) Tissue response to polyester mesh for hernia repair: an ultramicroscopic study in man. Hernia 2: 107–112
Usher FC, Fries JG, Ochsner JL, Tuttle LL (1959) Marlex mesh. A new plastic mesh for replacing tissue defects. Clinical study. Arch Surg 78: 138–145
Usher FC (1961) Knitted marlex mesh. An improved Marlex prosthesis for repairing hernias and others tissue defects. Arch Surg 82: 771–3
Wantz G (1989) Giant prosthetic reinforcement of the visceral sac for the management of hernias of the groin at high risk of recurrence. Surg Gynec Obstet 168: 408–13
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Coda, A., Botto-Micca, F., Quaglino, F. et al. In vivo tissue reaction to different prosthetic materials in abdominal wall hernia repair. Hernia 4, 206–211 (2000). https://doi.org/10.1007/BF01201068
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01201068