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G proteins and regulation of adenylyl cyclase

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Bioscience Reports

Abstract

The function and structures of G proteins and their role in the regulation of adenylyl cyclase is reviewed.

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References

  1. Rall, T. W., Sutherland, E. W. and Berthet, J. (1957)J. Biol. Chem. 224:463–475.

    PubMed  Google Scholar 

  2. Murad, F., Chi, Y.-M., Rall, T. W. and Sutherland, E. W. (1962)J. Biol. Chem. 237:1233–1238.

    PubMed  Google Scholar 

  3. Rall, T. W. and Sutherland, E. W. (1961)Cold Spring Harbor Symposia on Quantitative Biology 26:347–354.

    PubMed  Google Scholar 

  4. Birnbaumer, L. and Rodbell, M. (1969)J. Biol. Chem. 244:3477–3482.

    PubMed  Google Scholar 

  5. Limbird, L. E. and Lefkowitz, R. J. (1977)J. Biol. Chem. 252:799–802.

    PubMed  Google Scholar 

  6. Haga, T., Haga, K. and Gilman, A. G. (1977)J. Biol. Chem. 252:5776–5782.

    PubMed  Google Scholar 

  7. Rodbell, M., Birnbaumer, L. and Pohl, S. L. (1969) in:The Role of Adenyl Cyclase and Cyclic 3′,5′-AMPin Biological Systems. Fogarty International Center Proceedings, No. 4 (Anonymous) pp. 59–76, National Institutes of Health, Bethesda, MD.

    Google Scholar 

  8. Rodbell, M., Birnbaumer, L., Pohl, S. L. and Krans, H. M. J. (1971)J. Biol. Chem. 246:1877–1882.

    PubMed  Google Scholar 

  9. Jakobs, K. H., Aktories, K. and Schultz, G. (1979)Arch. Pharm. 310:113–119.

    Google Scholar 

  10. Cassel, D. and Selinger, Z. (1976)Biochem. Biophys. Acta 452:538–551.

    PubMed  Google Scholar 

  11. Londos, C., Salomon, Y., Lin, M. C., Harwood, J. P., Schramm, M., Wolff, J. and Rodbell, M. (1974)Proc. Natl. Acad. Sci. U.S.A. 71:3087–3090.

    PubMed  Google Scholar 

  12. Schramm, M. and Rodbell, M. (1975)J. Biol. Chem. 250:2232–2237.

    PubMed  Google Scholar 

  13. Maguire, M. E., Van Arsdale, P. M. and Gilman, A. G. (1976)Mol. Pharmacol. 12:335–339.

    PubMed  Google Scholar 

  14. Neer, E. J. (1974)J. Biol. Chem. 249:6527–6531.

    PubMed  Google Scholar 

  15. Daniel, V., Litwack, G. and Tomkins, G. M. (1973)Proc. Natl. Acad. Sci. U.S.A. 70:76–79.

    PubMed  Google Scholar 

  16. Bourne, H. R., Coffino, P. and Tomkins, G. M. (1975)Science 187:750–752.

    PubMed  Google Scholar 

  17. Insel, P. A., Maguire, M. E., Oilman, A. G., Bourne, H. R., Coffino, P. and Melmon, K. L. (1976)Mol. Pharmacol. 12:1062–1069.

    PubMed  Google Scholar 

  18. Haga, T., Ross, E. M. Anderson, H. J. and Gilman, A. G. (1977)Proc. Natl. Acad. Sci. U.S.A. 74:2016–2020.

    PubMed  Google Scholar 

  19. Ross, E. M. and Gilman, A. G. (1977)Proc. Natl. Acad. Sci. U.S.A. 74:3715–3719.

    PubMed  Google Scholar 

  20. Ross, E. M. and Gilman, A. G. (1977)J. Biol. Chem. 252:6966–6969.

    PubMed  Google Scholar 

  21. Ross, E. M., Hewlett, A. C., Ferguson, K. M. and Gilman, A. G. (1978)J. Biol. Chem. 253:6401–6412.

    PubMed  Google Scholar 

  22. Pfeuffer, T. (1977)J. Biol. Chem. 252:7224–7234.

    PubMed  Google Scholar 

  23. Howlett, A. C. and Gilman, A. G. (1980)J. Biol. Chem. 255:2861–2866.

    PubMed  Google Scholar 

  24. Northup, J. K., Sternweis, P. C., Smigel, M. D., Schleifer, L. S., Ross, E. M. and Gilman, A. G. (1980)Proc. Natl. Acad. Sci. U.S.A. 77:6561–6520.

    PubMed  Google Scholar 

  25. Sternweis, P. C., Northup, J. K., Smigel, M. D. and Gilman, A. G. (1981)J Biol. Chem. 256:11517–11526.

    PubMed  Google Scholar 

  26. Northup, J. K., Smigel, M. D. and Gilman, A. G. (1982)J. Biol. Chem. 257:11416–11423.

    PubMed  Google Scholar 

  27. Northup, J. K., Smigel, M. D., Sternweis, P. C. and Gilman, A. G. (1983)J. Biol. Chem. 258:11369–11376.

    PubMed  Google Scholar 

  28. Howlett, A. C., Sternweis, P. C., Macik, B. A., Van Arsdale, P. M. and Gilman, A. G. (1979)J. Biol. Chem. 254:2287–2295.

    PubMed  Google Scholar 

  29. Sternweis, P. C. and Gilman, A. G. (1982)Proc. Natl. Acad. Sci. U.S.A. 79:4888–4891.

    PubMed  Google Scholar 

  30. Gill, D. M. and Meren, R. (1978)Proc. Natl. Acad. Sci. U.S.A. 75:3050–3054.

    PubMed  Google Scholar 

  31. Moss, J. and Vaughan, M. (1977)J. Biol. Chem. 252, 2455–2457.

    PubMed  Google Scholar 

  32. Kaslow, H. R., Farfel, Z., Johnson, G. L. and Bourne, H. R. (1979)Mol. Pharmacol. 15:472–483.

    PubMed  Google Scholar 

  33. Schleifer, L. S., Kahn, R. A., Hanski, E., Northup, J. K., Sternweis, P. C. and Gilman, A. G. (1982)J. Biol. Chem. 257:20–23.

    PubMed  Google Scholar 

  34. Kahn, R. A. and Gilman, A. G. (1984)J. Biol Chem. 259:6228–6234.

    PubMed  Google Scholar 

  35. Kahn, R. A. and Gilman, A. G. (1986)J. Biol. Chem. 261:7906–7911.

    PubMed  Google Scholar 

  36. Rothman, J. E. (1994)Nature 372:55–63.

    PubMed  Google Scholar 

  37. Brown, H. A., Gutowski, S., Moomaw, C. R., Slaughter, C. and Sternweis, P. C. (1993)Cell 75:1137–1144.

    PubMed  Google Scholar 

  38. Hazeki, O. and Ui, M. (1981)J. Biol. Chem. 256:2856–2862.

    PubMed  Google Scholar 

  39. Katada, T. and Ui, M. (1982)J. Biol. Chem. 257:7210–7216.

    PubMed  Google Scholar 

  40. Bokoch, G. M., Katada, T., Northup, J. K., Hewlett, E. L. and Gilman, A. G. (1983)J. Biol. Chem. 258:2072–2075.

    PubMed  Google Scholar 

  41. Bokoch, G. M., Katada, T., Northup, J. K., Ui, M. and Gilman, A. G. (1984)J. Biol. Chem. 259:3560–3567.

    PubMed  Google Scholar 

  42. Katada, T., Bokoch, G. M., Northup, J. K., Ui, M. and Gilman, A. G. (1984)J. Biol. Chem. 259:3568–3577.

    PubMed  Google Scholar 

  43. Katada, T., Northup, J. K., Bokoch, G. M., Ui, M. and Gilman, A. G. (1984)J. Biol. Chem. 259:3578–3585.

    PubMed  Google Scholar 

  44. Katada, T., Bokoch, G. M., Smigel, M. D., Ui, M. and Gilman, A. G. (1984)J. Biol. Chem. 259:3586–3595.

    PubMed  Google Scholar 

  45. Miki, N., Keims, J. J., Marcus, F. R., Freeman, J. and Bitensky, M. W. (1973)Proc. Natl. Acad. Sci. U.S.A. 70:3820–3824.

    PubMed  Google Scholar 

  46. Wheeler, G. L. and Bitensky, M. W. (1977)Proc. Natl. Acad. Sci. U.S.A. 74:4238–4242.

    PubMed  Google Scholar 

  47. Kuhn, H. (1980)Nature 283:587–589.

    PubMed  Google Scholar 

  48. Fung, B. K.-K., Hurley, J. B. and Stryer, L. (1981)Proc. Natl. Acad. Sci. U.S.A. 78:152–156.

    PubMed  Google Scholar 

  49. Manning, D. R. and Gilman, A. G. (1983)J. Biol. Chem. 258:7059–7063.

    PubMed  Google Scholar 

  50. Hildebrandt, J. D., Codina, J., Risinger, R. and Birnbaumer, L. (1984)J. Biol. Chem. 259:2039–2042.

    PubMed  Google Scholar 

  51. May, D. C., Ross, R. M., Gilman, A. G. and Smigel, M. D. (1985)J. Biol. Chem. 260:15829–15833.

    PubMed  Google Scholar 

  52. Sternweis, P. C. and Robishaw, J. D. (1984)J. Biol. Chem. 259:13806–13813.

    PubMed  Google Scholar 

  53. Neer, E. J., Lok, J. M. and Wolf, L. G. (1984)J. Biol. Chem. 259:14222–14229.

    PubMed  Google Scholar 

  54. Litosch, I., Wallis, C. and Fain, J. N. (1985)J. Biol. Chem. 260:5464–5471.

    PubMed  Google Scholar 

  55. Cockcroft, S. and Gomperts, B. D. (1985)Nature 314:534–536.

    PubMed  Google Scholar 

  56. Hurley, J. B., Simon, M. L., Teplow, D. B., Robishaw, J. D. and Gilman, A. G. (1984)Science 226:860–862.

    PubMed  Google Scholar 

  57. Lochrie, M. A., Hurley, J. B. and Simon, M. I. (1985)Science 228:96–99.

    PubMed  Google Scholar 

  58. Yatsunami, K. and Khorana, H. G. (1985)Proc. Natl. Acad. Sci. U.S.A. 82:4316–4320.

    PubMed  Google Scholar 

  59. Gilman, A. G. (1987)Annu. Rev. Biochem. 56:615–649.

    PubMed  Google Scholar 

  60. Ross, E. M. (1989)Neuron 3:141–152.

    PubMed  Google Scholar 

  61. Brown, A. M. and Birnbaumer, L. (1990)Annu. Rev. Physiol. 52:197–213.

    PubMed  Google Scholar 

  62. Bourne, H. R., Sanders, D. A. and McCormick, F. (1990)Nature 348:125–132.

    PubMed  Google Scholar 

  63. Bourne, H. R., Sanders, D. A. and McCormick, F. (1991)Nature 349:117–127.

    PubMed  Google Scholar 

  64. Dohlman, H. G., Thorner, J., Caron, M. G. and Lefkowitz, R. J. (1991)Annu. Rev. Biochem. 60:653–688.

    PubMed  Google Scholar 

  65. Kaziro, Y., Itoh, H., Kozasa, T., Nakafuku, M. and Satoh, T. (1991)Annu. Rev. Biochem. 60:349–400.

    PubMed  Google Scholar 

  66. Simon, M. L., Strathmann, M. P. and Gautam, N. (1991)Science 252:802–808.

    PubMed  Google Scholar 

  67. Spiegel, A. M., Backlund, P. S., Jr., Butrynski, J. E., Jones, T. L. Z. and Simonds, W. F. (1991)Trends Biochem, Sci. 16:338–341.

    Google Scholar 

  68. Hepler, J. R. and Gilman, A. G. (1992)Trends Biochem. Sci 17:383–387.

    PubMed  Google Scholar 

  69. Clapham, D. E. and Neer, E. J. (1993)Nature 365:403–406.

    PubMed  Google Scholar 

  70. Iñiguez-Lluhi, J., Kleuss, C. and Gilman, A. G. (1993)Trends Cell Biol. 3:230–236.

    PubMed  Google Scholar 

  71. Buss, J. E., Mumby, S. M., Casey, P. J., Gilman, A. G. and Sefton, B. M. (1987)Proc. Natl. Acad. Sci. U.S.A. 84:7493–7497.

    PubMed  Google Scholar 

  72. Mumby, S. M., Heuckeroth, R. O., Gordon, J. I. and Gilman, A. G. (1990)Proc. Natl. Acad. Sci. U.S.A. 87:728–732.

    PubMed  Google Scholar 

  73. Jones, T. L. Z., Simonds, W. F., Merendino, J. J., Jr., Brann, M. R., and Spiegel, A. M. (1990)Proc. Natl. Acad. Sci. U.S.A. 87:568–572.

    PubMed  Google Scholar 

  74. Linder, M. E., Pang, I.-H., Duronio, R. J., Gordon, J. L., Sternweis, P. C. and Gilman, A. G. (1991)J. Biol. Chem. 266:4654–4659.

    PubMed  Google Scholar 

  75. Taussig, R., Iniguez-Lluhi, J. and Gilman, A. G. (1993)Science 261:218–221.

    PubMed  Google Scholar 

  76. Linder, M. E., Middleton, P., Hepler, J. R., Taussig, R., Gilman, A. G. and Mumby, S. M. (1993)Proc. Natl. Acad. Sci. U.S.A. 90:3675–3679.

    PubMed  Google Scholar 

  77. Mumby, S. M., Kleuss, C. and Gilman, A. G. (1994)Proc. Natl. Acad. Sci. U.S.A. 91:2800–2804.

    PubMed  Google Scholar 

  78. Wedegaertner, P. B. and Bourne, H. R. (1994)Cell 77:1063–1070.

    PubMed  Google Scholar 

  79. Fukada, Y., Takao, T., Ohguro, H., Yoshizawa, T., Akino, T. and Shimonishi, Y. (1990)Nature 346:658–660.

    PubMed  Google Scholar 

  80. Yamane, H. K., Farnsworth, C. C., Xie, H., Howald, W., Fung, B. K.-K., Clarke, S. Gelb, M. H. and Glomset, J. A. (1990)Proc. Natl. Acad. Sci. U.S.A. 87:5868–5872.

    PubMed  Google Scholar 

  81. Mumby, S. M., Casey, P. J., Gilman, A. G., Gutowski, S. and Sternweis, P. C. (1990)Proc. Natl. Acad. Sci. U.S.A. 87:5873–5877.

    PubMed  Google Scholar 

  82. Iñiguez-Lluhi, J. A., Simon, M. I., Robishaw, J. D. and Gilman, A. G. (1992)J. Biol. Chem. 267:23409–23417.

    PubMed  Google Scholar 

  83. Graziano, M. P., Freissmuth, M. and Gilman, A. G. (1988)J. Biol. Chem. 264:409–418.

    Google Scholar 

  84. Van Dop, C., Tsubokawa, M., Bourne, H. R. and Ramachandran, J. (1984)J. Biol. Chem. 259:696–698.

    PubMed  Google Scholar 

  85. West, R. E., Jr., Moss, J., Vaughan, M., Liu, T. and Liu, T.-Y. (1985)J. Biol. Chem. 260:14428–14430.

    PubMed  Google Scholar 

  86. Noel, J. P., Hamm, H. E. and Sigler, P. B. (1993)Nature 366:654–663.

    PubMed  Google Scholar 

  87. Lambright, D. G., Noel, J. P., Hamm, H. E. and Sigler, P. B. (1994)Nature 369:621–628.

    PubMed  Google Scholar 

  88. Coleman, D. E., Berghuis, A. M., Lee, E., Linder, M. E., Gilman, A. G. and Sprang, S. R. (1994)Science 265:1405–1412.

    PubMed  Google Scholar 

  89. Bigay, J., Deterre, P., Pfister, C. and Chabre, M. (1985)FEBS Lett. 191:181–185.

    PubMed  Google Scholar 

  90. Higashijima, T., Graziano, M. P., Suga, H., Kainosho, M. and Gilman, A. G. (1991)J. Biol. Chem. 266:3396–3401.

    PubMed  Google Scholar 

  91. Graziano, M. P. and Gilman, A. G. (1989)J. Biol. Chem. 264:15475–15482.

    PubMed  Google Scholar 

  92. Landis, C. A., Masters, S. B., Spada, A., Pace, A. M., Bourne, H. R. and Vallar, L. (1989)Nature 340:692–696.

    PubMed  Google Scholar 

  93. Freissmuth, M. and Gilman, A. G. (1989)J. Biol. Chem. 264:21907–21914.

    PubMed  Google Scholar 

  94. Masters, S. B., Miller, R. T., Chi, M.-H., Chang, F.-H., Beiderman, B., Lopez, N. G. and Bourne, H. R. (1989)J. Biol. Chem. 264:15467–15474.

    PubMed  Google Scholar 

  95. Mixon, M., Coleman, D. E., Berghuis, A. M., Lee, E., Gilman, A. G. and Sprang, S. R. (1994) (manuscriptin preparation).

  96. Coulter, S. and Rodbell, M. (1992)Proc. Natl. Acad. Sci. U.S.A. 89, 5842–5846.

    PubMed  Google Scholar 

  97. Robishaw, J. D., Smigel, M. D. and Gilman, A. G. (1986)J. Biol. Chem. 261:9587–9590.

    PubMed  Google Scholar 

  98. Bray, P., Carter, A., Simons, C., Guo, V., Puckett, C., Kamholz, J., Spiegel, A. and Nirenberg, M. (1986)Proc. Natl. Acad. Sci. U.S.A. 83:8893–8897.

    PubMed  Google Scholar 

  99. Kozasa, T., Itoh, H., Tsukamoto, T. and Kaziro, Y. (1988)Proc. Natl. Acad. Sci. U.S.A. 85:2081–2085.

    PubMed  Google Scholar 

  100. Jones, D. T. and Reed, R. R. (1989)Science 244:790–795.

    PubMed  Google Scholar 

  101. Yatani, A., Codina, J., Imoto, T., Revees, J. P., Birnbaumer, L. and Brown, A. M. (1987)Science 238:1288–1292.

    PubMed  Google Scholar 

  102. Schubert, B., VanDongen, A. M. J., Kirsch, G. E. and Brown, A. M. (1989)Science 245:516–519.

    PubMed  Google Scholar 

  103. Lerea, C. L., Somers, D. E., Hurley, J. B., Klock, I. B. and Bunt-Milam, A. H. (1986)Science 234:77–80.

    PubMed  Google Scholar 

  104. McLaughlin, S. K., McKinnon, P. J. and Margolskee, R. F. (1992)Nature 357:563–569.

    PubMed  Google Scholar 

  105. Taussig, R., Tang, W.-J., Hepler, J. R. and Gilman, A. G. (1994)J. Biol. Chem. 269:6093–6100.

    PubMed  Google Scholar 

  106. Codina, J., Yatani, A., Grenet, D., Brown, A. M. and Birnbaumer, L. (1987)Science 236:442–444.

    PubMed  Google Scholar 

  107. Logothetis, D. E., Kurachi, Y., Galper, J., Neer, E. J. and Clapham, D. E. (1987)Nature 325:321–326.

    PubMed  Google Scholar 

  108. Stow, J. L., de Almeida, J. B., Narula, N., Holtzman, E. J., Ercolani, L. and Ausiello, D. A. (1991)J. Cell Biol. 114:1113–1124.

    PubMed  Google Scholar 

  109. Donaldson, J. G., Kahn, R. A., Lippincott-Schwartz, J. and Klausner, R. D. (1991)Science 254:1197–1199.

    PubMed  Google Scholar 

  110. Ktistakis, N. T., Linder, M. E. and Roth, M. G. (1992)Nature 356:344–346.

    PubMed  Google Scholar 

  111. Wong, Y. H., Conklin, B. R. and Bourne, H. R. (1992)Science 255:339–341.

    PubMed  Google Scholar 

  112. Kozasa, T. and Gilman, A. G. (1995)J. Biol. Chem. 270:1734–1741.

    PubMed  Google Scholar 

  113. Casey, P. J., Fong, H. K. W., Simon, M. I. and Gilman, A. G. (1990)J. Biol. Chem. 265:2383–2390.

    PubMed  Google Scholar 

  114. Hescheler, J., Rosenthal, W., Trautwein, W. and Schultz, G. (1987)Nature 325:445–447.

    PubMed  Google Scholar 

  115. Strittmatter, S. M., Valenzuela, D., Kennedy, T. E., Neer, E. J. and Fishman, M. C. (1990)Nature 344:836–841.

    PubMed  Google Scholar 

  116. Strittmatter, S. M., Valenzuela, D., Sudo, Y., Linder, M. E. and Fishman, M. C. (1991)J. Biol. Chem. 266:22465–22471.

    PubMed  Google Scholar 

  117. Strathmann, M., Wilkie, T. M. and Simon, M. I. (1989)Proc. Nad. Acad. Sci. U.S.A. 86:7407–7409.

    Google Scholar 

  118. Taylor, S. J., Smith, J. A. and Exton, J. H. (1990)J. Biol. Chem. 265:17150–17156.

    PubMed  Google Scholar 

  119. Waldo, G. L., Boyer, J. L., Morris, A. J. and Harden, T. K. (1991)J. Biol. Chem. 266:14217–14225.

    PubMed  Google Scholar 

  120. Smrcka, A. V., Hepler, J. R., Brown, K. O. and Sternweis, P. C. (1991)Science 251:804–807.

    PubMed  Google Scholar 

  121. Berstein, G., Blank, J. L., Jhon, D. Y., Exton, J. H., Rhee, S. G. and Ross, E. M. (1992)Cell 70: 411–418.

    PubMed  Google Scholar 

  122. Parks, S. and Wieschaus, E. (1991)Cell 64: 447–458.

    PubMed  Google Scholar 

  123. Chan, A. M. L., Fleming, R. P., Mcgovern, E. S., Chedid, M., Miki, T. and Aaronson, S. A., (1993)Mol. Cell. Biol. 13:762–768.

    PubMed  Google Scholar 

  124. Xu, N. Z., Bradley, L., Ambdukar, I. and Gutkind, J. S. (1993)Proc. Natl. Acad. Sci U.S.A. 90:6741–6745.

    PubMed  Google Scholar 

  125. Higashijima, T., Ferguson, K. M., Sternweis, P. C., Smigel, M. D. and Gilman, A. G. (1987)J. Biol. Chem. 262:762–766.

    PubMed  Google Scholar 

  126. Cerione, R. A., Staniszewski, C., Caron, M. G., Lefkowitz, R. J., Codina, J. and Birnbaumer, L., (1985)Nature 318:293–295.

    PubMed  Google Scholar 

  127. Gilman, A. G. (1984)Cell 36:577–579.

    PubMed  Google Scholar 

  128. Florio, V. A. and Sternweis, P. C. (1985)J. Biol. Chem. 260:3477–3483.

    PubMed  Google Scholar 

  129. Dietzel, C. and Kurjan, J. (1987)Cell 50:1001–1010.

    PubMed  Google Scholar 

  130. Tang, W.-J., Krupinski, J. and Gilman, A. G. (1991)J. Biol. Chem. 266:8595–8603.

    PubMed  Google Scholar 

  131. Tang, W.-J. and Gilman, A. G. (1991)Science 254:1500–1503.

    PubMed  Google Scholar 

  132. Taussig, R., Quarmby, L. M. and Gilman, A. G. (1993)J. Biol. Chem. 268:9–12.

    PubMed  Google Scholar 

  133. Camps, M., Hou, C., Sidiropoulos, D., Stock, J. B., Jakobs, K. H. and Gierschik, P. (1992)Eur. J. Biochem. 206:821–831.

    PubMed  Google Scholar 

  134. Camps, M., Carozzi, A., Schnabel, P., Scheer, A., Parker, P. J. and Gierschik, P. (1992)Nature 360:684–686.

    PubMed  Google Scholar 

  135. Ueda, N., Iñiguez-Lluhi, J. A., Lee, E., Smrcka, A. V., Robishaw, J. D. and Gilman, A. G., (1994)J. Biol. Chem. 269:4388–4395.

    PubMed  Google Scholar 

  136. Kisselev, O. and Gautam, N. (1993)J. Biol. Chem. 268:24519–24522.

    PubMed  Google Scholar 

  137. Kleuss, C., Hescheler, J., Ewel, C., Rosenthal, W., Schultz, G. and Wittig, B. (1991)Nature 353:43–48.

    PubMed  Google Scholar 

  138. Kleuss, C., Scherubl, H., Hescheler, J., Schultz, G. and Wittig, B. (1992)Nature 358:424–426.

    PubMed  Google Scholar 

  139. Kleuss, C., Scherubl, H., Hescheler, J., Schultz, G. and Wittig, B. (1993)Science 259:832–834.

    PubMed  Google Scholar 

  140. Pfeuffer, T. and Metzger, H. (1982)FEBS Lett. 146:369–375.

    Google Scholar 

  141. Smigel, M. D. (1986)J. Biol. Chem. 261:1976–1982.

    PubMed  Google Scholar 

  142. Krupinski, J., Coussen, F., Bakalyar, H. A., Tang, W.-J., Feinstein, P. G., Orth, K., Slaughter, C., Reed, R. R. and Gilman, A. G. (1989)Science 244:1558–1564.

    PubMed  Google Scholar 

  143. Tang, W.-J. and Gilman, A. G. (1992)Cell 70:869–872.

    PubMed  Google Scholar 

  144. Iyengar, R. (1993)FASEB J. 7:768–775.

    PubMed  Google Scholar 

  145. Taussig, R. and Gilman, A. G. (1995)J. Biol. Chem. 270:1–4.

    PubMed  Google Scholar 

  146. Kataoka, T., Broek, D. and Wigler, M. (1985)Cell 43:493–505.

    PubMed  Google Scholar 

  147. Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Brock, D., Cameron, S., Broach, J., Matsumoto, K. and Wigler, M. (1985)Cell 40:27–36.

    PubMed  Google Scholar 

  148. Nakane, M., Arai, K., Saheki, S., Kuno, T., Buechler, W. and Murad, F. (1990)J. Biol. Chem. 265:16841–16845.

    PubMed  Google Scholar 

  149. Chinkers, M. and Wilson, E. M. (1992)J. Biol. Chem. 267:18589–18597.

    PubMed  Google Scholar 

  150. Gao, B. and Gilman, A. G. (1991)Proc. Natl. Acad. Sci. U.S.A. 88:10178–10182.

    PubMed  Google Scholar 

  151. Sattin, A., Rall, T. W. and Zanella, J. (1975)J. Pharmacol. Exp. Ther. 192:22–32.

    PubMed  Google Scholar 

  152. Tang, W. -J. and Gilman, A. G. (1994) (submitted for publication).

  153. Brandt, D. R. and Ross, E. M. (1986)J. Biol. Chem. 261:1656–1664.

    PubMed  Google Scholar 

  154. Linder, M. E. and Gilman, A. G. (1992)Sci. Am. 267(1):56–65.

    Google Scholar 

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The Nobel lecture given on December 8, 1994 by Dr Alfred Gilman and published inLes Prix Nobel 1994, printed by Norstedts Tryckeri, Stockholm, Sweden, republished here with the permission of the Nobel Foundation, the copyright holder.

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Gilman, A.G. G proteins and regulation of adenylyl cyclase. Biosci Rep 15, 65–97 (1995). https://doi.org/10.1007/BF01200143

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