Conclusions
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1.
The N-hydroxysuccinimide esters of dansylated amino acids (glycine, L-alanine, L-valine, and L-phenylalanine) and β-anthracenesulfonylglycine have been synthesized and characterized.
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2.
The N-hydroxysuccinimide esters of fluoresceinylaminothiocarbonylglycine and α-naphthylaminocarbonylglycine, which are labile compounds, have been obtained. The structure of the N-hydroxysuccinimide ester of fluoresceinylaminothiocarbonylglycine has been confirmed by a reversed synthesis.
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3.
The following dipeptidyl-tRNAs with fluorescent labels on the N terminus of the peptide part of the molecule have been synthesized from the N-hydroxysuccinimide esters obtained: dansylaminoacyl-[14C]Phe-tRNA (where aminoacyl may be Gly, L-Ala, L-Val, or L-Phe), β-anthracenylsulfonylglycyl-[14C]Phe-tRNA, fluoresceinylaminothiocarbonyl-[14C]Phe-tRNA, and α-naphthylaminocarbonylglycyl-[14C]Phe-tRNA.
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For report 15 see [1].
Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 3, pp. 647–653, March, 1977.
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Aleksandrova, L.A., Kutuzova, T.M., Kraevskii, A.A. et al. Aminoacyl derivatives of nucleosides, nucleotides, and polynucleotides. Russ Chem Bull 26, 583–589 (1977). https://doi.org/10.1007/BF01179472
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DOI: https://doi.org/10.1007/BF01179472