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Toxicity testing of sediment elutriates based on inhibition of alpha-glucosidase biosynthesis inBacillus licheniformis

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Abstract

An assay based on inhibition of a-glucosidase biosynthesis (AGB) inBacillus licheniformis was used to test the toxicity of sediment elutriates from hazardous waste sites in Florida. The assay gave the same general classification of toxicity as Microtox in 85% of the 66 elutriates screened. For the ten most inhibitory elutriates, the AGB assay consistently gave lower EC50s than Microtox. These samples were the highest in concentrations of cadmium, copper, lead, zinc of all those screened, suggesting that the AGB assay is particularly sensitive to heavy metals.

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Campbell, M., Bitton, G. & Koopman, B. Toxicity testing of sediment elutriates based on inhibition of alpha-glucosidase biosynthesis inBacillus licheniformis . Arch. Environ. Contam. Toxicol. 24, 469–472 (1993). https://doi.org/10.1007/BF01146163

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  • DOI: https://doi.org/10.1007/BF01146163

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