Abstract
Glutamate had no significant effect on the uptake of 0.025 mM cystine by isolated rat renal cortical tubules and brushborder membrane vesicles in contrast to lysine which significantly inhibits cystine transport. Glutamate, however, markedly inhibited cystine uptake by rat renal tubule cells grown in a serum-free, hormonally defined media for 5 days. Lysine also inhibited cystine transport in these cultured renal tubule cells.
This is a preview of subscription content, log in via an institution to check access.
References
Foreman, J. W., Hwang, S. M., and Segal, S. (1980).Metabolism 29:53–61.
Segal, S., McNamara, P. D., and Pepe, L. M. (1977).Science 197:169–171.
McNamara, P. D., Pepe, L. M., and Segal, S. (1981).Biochem. J. 194:443–449.
Ozegovic, G., McNamara, P. D., and Segal, S. (1982).Biosci. Rep. 2:913–920.
Segal, S. and Thier, S. O. (1983). Cystinuria. In:The Biochemical Basis of Inherited Metabolic Diseases (J. B. Stanbury, J. B. Wyngaarden, J. B. Fredrickson, J. L. Goldstein, and M. S. Brown (Eds.), 5th Edition, McGraw-Hill, New York, NY.
Bovee, K. C., and Segal, S. (1984).Metabolism 33:602–607.
Griffith, O. W. (1981).J. Biol. Chem. 256:12263–12268.
Robson, E. B., and Rose, G. A. (1957).Clin. Sci. 16:75–91.
Groth, U., and Rosenberg, L. E. (1972).J. Clin. Invest. 51:2130–2142.
Bannai, S., and Kitamura, E. (1980).J. Biol. Chem. 255:2372–2376.
Bannai, S., and Kitamura, E. (1981).J. Biol. Chem. 256:5770–5772.
Bannai, S., and Kitamura, E. (1982).Biochim. Biophys. Acta 721:1–10.
Takada, A., and Bannai, S. (1984).J. Biol. Chem. 259:2441–2445.
Schafer, J. A., and Watkins, M. L. (1984).Pflugers Arch. 401:143–151.
Burg, M. B. and Orloff, J. (1962).Amer. J. Physiol. 203:327–330.
Gazzola, G. C., Dall'Asta, V., Franchi-Gazzola, R., and White, M. F. (1981).Anal. Biochem. 115:368–374.
States, B., Harris, D., and Segal, S. (1974).J. Clin. Invest. 53:1003–1016.
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951).J. Biol. Chem. 193:265–275.
Booth, A. G., and Kenny, A. J. (1974).Biochem. J. 142:575–581.
Weiss, S. D., McNamara, P. D., Pepe, L. M., and Segal, S. (1978).J. Membrane Biol. 48:91–105.
States, B., Foreman, J. W., Lee, J. Harris, D., and Segal, S.Biochem. Med., in press.
Taub, M., and Sato, G. H. (1979).J. Supramol. Struct. 11:207–216.
Becker, J. H., and Willis, J. S. (1979).J. Cell. Physiol. 99:427–440.
Rabito, C. A., and Karish, M. V. (1982).J. Biol. Chem. 257:6802–6808.
Curthoys, N. P., and Hughey, R. P. (1979).Enzyme 24:383–403.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Foreman, J.W., McNamara, P.D., Bowring, M.A. et al. Cystine-glutamate transport interactions in rat renal cortical tubules, brushborder vesicles, and cultured renal tubule cells. Biosci Rep 6, 113–119 (1986). https://doi.org/10.1007/BF01145186
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01145186