Summary
This review examines various aspects of iron metabolism in mammalian and bacterial cells which support the hypothesis of the existence and the biological significance of an intracellular pool of low-molecular mass iron complexes.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Aisen P (1989) Physical biochemistry of transferrin: update 1984–1988. In: Loehr TM (ed) Iron carriers and iron proteins. VCH Publishers, Weinheim, pp 353–371
Bagg A, Neilands JB (1987) Ferric uptake regulation protein acts as a repressor, employing iron(II) as a cofactor to bind the operator of an iron transport operon inEscherichia coli. Biochemistry 26:5471–5477
Biemond P, Swaak AJG, Van Eijk HG, Koster JF (1988) Superoxide-dependent iron release from ferritin in inflammatory diseases. Free Rad Biol Med 4:185–198
Bolann BJ, Ulvik RJ (1990) On the limited ability of superoxide to release iron from ferritin. Eur J Biochem 193:899–904
Crichton RR (1984) Iron uptake and utilization by mammalian cells II. Intracellular iron utilization. Trends Biochem Sci 9:283–286
Crichton RR, Charloteaux-Wauters M (1987) Iron transport and storage. Eur J Biochem 164:485–506
Halliwell B, Gutteridge JMC (1989) Free radicals in biology and medicine. Clarendon Press, Oxford
Harrisson PM, Lilley TH (1989) Ferritin. In: Loehr TM (ed) Iron carriers and iron proteins. VCH Publishers, Weinheim, pp 123–238
Jacob A (1977) Low molecular weight intracellular iron transport compounds. Blood 50:433
Rouault TA, Tang CK, Kaptain S, Burgess WH, Haile DJ, Samaniego F, McBride OW, Harford JB, Klausner RD (1990) Cloning of the cDNA encoding an RNA regulatory protein — the human iron-responsive element-binding protein. Proc Natl Acad Sci USA 87:7958–7962
Sun IL, Navas P, Crane FL, Morre DJ, Low DH (1987) NADH-transferrin reductase in liver plasma membrane. J Biol Chem 262:15915–15921
Theil EC (1990) Regulation of ferritin and transferrin receptor in mRNAs. J Biol Chem 265:4771–4774
Thorstensen K, Romslo I (1990) The role of transferrin in the mechanism of cellular iron uptake. Biochem J 271:l-10
Weaver J, Pollack S (1989) Low-M r iron isolated from guinea pig reticulocytes as AMP-Fe and ATP-Fe complexes. Biochem J 261:787–792
Weaver J, Zhan H, Pollack S (1990) Mitochondria have Fe(III) receptors. Biochem J 265:415–419
Williams RJP (1982) Free manganese(II) and iron(II) cations can act as intracellular cell control. FEBS Lett 140:3–10
Winkelman G, Van Der Helm D, Neilands JB (eds) (1987) Iron transport in microbes, plants and animals. VCH Publishers, Weinheim
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fontecave, M., Pierre, J.L. Iron metabolism: The low-molecular-mass iron pool. Biol Metals 4, 133–135 (1991). https://doi.org/10.1007/BF01141302
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01141302