Abstract
A potent anti-herpetic compound was identified and purified to homogeneity from the leaves ofSapium sebiferum by plaque reduction assay using herpes simplex virus type 2. The chemical structure of the purified compound was determined by mass spectroscopy and proton and carbon-13 nuclear magnetic resonance as methyl gallate, methyl-3,4,5-trihydroxybenzoate. This is the first demonstration that methyl gallate is a potent anti-herpetic compoundin vitro, present in high concentration in the leaves ofS. sebiferum, a Chinese folk medicine for shingles.
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Kane, C.J.M., Menna, J.H. & Yeh, YC. Methyl gallate, methyl-3,4,5-trihydroxy-benzoate, is a potent and highly specific inhibitor of herpes simplex virusin vitro. I. Purification and characterization of methyl gallate fromSapium sebiferum . Biosci Rep 8, 85–94 (1988). https://doi.org/10.1007/BF01128975
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DOI: https://doi.org/10.1007/BF01128975