Abstract
The cellularonc- genesc-src andc-yes are expressed very differently during chicken embryonic development. Thec-src mRNA and its translational product are detectable at high levels in brain extracts of chicken embryos and adult chickens) whereas muscle extracts show an age-dependent decrease in the amounts ofc-src-specific mRNA and pp60c-src kinase activity. In contrast) the levels ofc-yes mRNA in brain, heart, and muscle are relatively low in early embryonic stages and increase later on to values comparable to those found for liver) while in adult animals the pattern ofc-yes expression is similar to that of thec-src gene. From the close correlation between the levels of pp60c -s r c its enzymatic activity, and its corresponding mRNA at a given stage of development and in given tissues) it appears that the expression of pp60c-src is primarily controlled at the level of transcription. It is suggested that because of the different patterns of expression) the two cellular oncogenes)c-src andc-yes ) play different roles in cell proliferation during early embryonic stages as well as in ensuing differentiation processes.
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Gessler, M., Barnekow, A. Differential expression of the cellular oncogenesc-src andc-yes in embryonal and adult chicken tissues. Biosci Rep 4, 757–770 (1984). https://doi.org/10.1007/BF01128817
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DOI: https://doi.org/10.1007/BF01128817